Please use this identifier to cite or link to this item:
標題: Comparison of Differential Pulse Voltammetry (DPV)-a new method of carbamazepine analysis-with Fluorescence Polarization Immunoassay (FPIA)
作者: Wang, H.Y.
Pan, M.L.
Su, Y.L.O.
Tsai, S.C.
Kao, C.H.
Sun, S.S.
Lin, W.
Project: Journal of Analytical Chemistry
期刊/報告no:: Journal of Analytical Chemistry, Volume 66, Issue 4, Page(s) 415-420.
Carbamazepine is a widely used anti-epileptic drug with narrow therapeutic range. Many methods have been developed for monitoring the serum drug level. Differential pulse voltammetry (DPV), an electrochemical method advantaged by simple, inexpensive, and relatively short analysis time, has recently been developed for carbamazepine detection. We used a newly developed DPV method with glassy carbon as a working electrode to determine the carbamazepine level. The performance of DPV is compared with the widely used fluorescence polarization immunoassay (FPIA) technique in precision, accuracy, linearity and detection limit. The precision, linearity and accuracy of the DPV and FPIA techniques were comparable at most clinical used levels. The detection limit was 1 mu g/mL for the DPV technique and 0.5 mu g/mL for the FPIA technique. The performance of the DPV technique was within the FDA guidelines for bioanalytical methods, which ensures the clinical applicability of the DPV technique. The DPV technique may have the potential to be a good alternative for carbamazepine analysis.
ISSN: 1061-9348
DOI: 10.1134/s1061934811040162
Appears in Collections:期刊論文

Show full item record

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.