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標題: Immunomagnetic reduction assay using high-T-c superconducting-quantum-interference-device-based magnetosusceptometry
作者: Chieh, J.J.
Yang, S.Y.
Horng, H.E.
Yu, C.Y.
Lee, C.L.
Wu, H.L.
Hong, C.Y.
Yang, H.C.
關鍵字: magnetic nanoparticles;squid;immunoassay
Project: Journal of Applied Physics
期刊/報告no:: Journal of Applied Physics, Volume 107, Issue 7.
Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3340861]
ISSN: 0021-8979
DOI: 10.1063/1.3340861
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