Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69777
標題: Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection
作者: Cheng, C.C.
Lee, Y.F.
Lin, N.N.
Wu, C.L.
Tung, K.C.
Chiu, Y.T.
關鍵字: multisystemic wasting syndrome;acute lung injury;matrix-metalloproteinase;pseudorabies virus;pulmonary fibrosis;gene-expression;collagen matrix;multiplex pcr;syndrome pmws;risk-factors
Project: Journal of Biomedicine and Biotechnology
期刊/報告no:: Journal of Biomedicine and Biotechnology.
摘要: 
Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS), typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs), extracellular collagen matrix (ECM) deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (P < .05). Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.
URI: http://hdl.handle.net/11455/69777
ISSN: 1110-7243
DOI: 10.1155/2011/245728
Appears in Collections:期刊論文

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