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|標題:||Honokiol Inhibits LPS-Induced Maturation and Inflammatory Response of Human Monocyte-Derived Dendritic Cells||作者:||Li, C.Y.
|關鍵字:||activated protein-kinase;nf-kappa-b;regulatory t-cells;natural plant;product;tumor-necrosis-factor;in-vitro;immune-responses;magnolia-officinalis;liposomal honokiol;oxidative stress||Project:||Journal of Cellular Physiology||期刊/報告no：:||Journal of Cellular Physiology, Volume 226, Issue 9, Page(s) 2338-2349.||摘要:||
Honokiol (HNK) is a phenolic compound isolated from the bark of houpu (Magnolia officinalis), a plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti-inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)-stimulated human monocyte-derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS-induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC-II on LPS-activated DCs, (2) reducing the production of TNF-alpha, IL-1 beta, IL-6, and IL-12p70 but increasing the production of IL-10 and TGF-beta 1 by LPS-activated DCs, (3) inhibiting the LPS-induced DC-elicited allogeneic T-cell proliferation, and (4) shifting the LPS-induced DC-driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKK alpha, and I kappa B alpha in LPS-activated DCs. Collectively, the findings show that the anti-inflammatory actions of HNK on LPS-induced DCs are associated with the NF-kappa B and mitogen-activated protein kinase (MAPK) signaling pathways. J. Cell. Physiol. 226: 2338-2349, 2011. (C) 2010 Wiley-Liss, Inc.
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