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標題: Honokiol Inhibits LPS-Induced Maturation and Inflammatory Response of Human Monocyte-Derived Dendritic Cells
作者: Li, C.Y.
Chao, L.K.
Wang, S.C.
Chang, H.Z.
Tsai, M.L.
Fang, S.H.
Liao, P.C.
Ho, C.L.
Chen, S.T.
Cheng, W.C.
Chiang, C.S.
Kuo, Y.H.
Hua, K.F.
Hsu, I.C.
關鍵字: activated protein-kinase;nf-kappa-b;regulatory t-cells;natural plant;product;tumor-necrosis-factor;in-vitro;immune-responses;magnolia-officinalis;liposomal honokiol;oxidative stress
Project: Journal of Cellular Physiology
期刊/報告no:: Journal of Cellular Physiology, Volume 226, Issue 9, Page(s) 2338-2349.
Honokiol (HNK) is a phenolic compound isolated from the bark of houpu (Magnolia officinalis), a plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti-inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)-stimulated human monocyte-derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS-induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC-II on LPS-activated DCs, (2) reducing the production of TNF-alpha, IL-1 beta, IL-6, and IL-12p70 but increasing the production of IL-10 and TGF-beta 1 by LPS-activated DCs, (3) inhibiting the LPS-induced DC-elicited allogeneic T-cell proliferation, and (4) shifting the LPS-induced DC-driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKK alpha, and I kappa B alpha in LPS-activated DCs. Collectively, the findings show that the anti-inflammatory actions of HNK on LPS-induced DCs are associated with the NF-kappa B and mitogen-activated protein kinase (MAPK) signaling pathways. J. Cell. Physiol. 226: 2338-2349, 2011. (C) 2010 Wiley-Liss, Inc.
ISSN: 0021-9541
DOI: 10.1002/jcp.22576
Appears in Collections:期刊論文

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