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|標題:||Green and efficient production of octyl hydroxyphenylpropionate using an ultrasound-assisted packed-bed bioreactor||作者:||Lee, C.C.
|關鍵字:||Esterification;Lipase;Packed-bed bioreactor;Solvent-free;Ultrasound;enzymatic-synthesis;phenolic-acids;antioxidants;lipase;lipophilization;derivatives;plants||Project:||Journal of Industrial Microbiology & Biotechnology||期刊/報告no：:||Journal of Industrial Microbiology & Biotechnology, Volume 39, Issue 4, Page(s) 655-660.||摘要:||
A solvent-free system to produce octyl hydroxyphenylpropionate (OHPP) from p-hydroxyphenylpropionic acid (HPPA) and octanol using immobilized lipase (Novozym(A (R)) 435) as a catalyst in an ultrasound-assisted packed-bed bioreactor was investigated. Response-surface methodology (RSM) and a three-level-three-factor Box-Behnken design were employed to evaluate the effects of reaction temperature (x (1)), flow rate (x (2)) and ultrasonic power (x (3)) on the percentage of molar production of OHPP. The results indicate that the reaction temperature and flow rate were the most important variables in optimizing the production of OHPP. Based on a ridge max analysis, the optimum conditions for OHPP synthesis were predicted to consist of a reaction temperature of 65A degrees C, a flow rate of 0.05 ml/min and an ultrasonic power of 1.74 W/cm(2) with a yield of 99.25%. A reaction was performed under these optimal conditions, and a yield of 99.33 +/- A 0.1% was obtained.
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