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|標題:||Magnetic nanoparticles for high-sensitivity detection on nucleic acids via superconducting-quantum-interference-device-based immunomagnetic reduction assay||作者:||Yang, S.Y.
|Project:||Journal of Magnetism and Magnetic Materials||期刊/報告no：:||Journal of Magnetism and Magnetic Materials, Volume 323, Issue 6, Page(s) 681-685.||摘要:||
In this work, we investigate the feasibility of detecting quantitatively DNA molecules utilizing the technology named after the immunomagnetic reduction (IMR) assay. Magnetic nanoparticles dispersed in a phosphate buffer saline solution were bio-functionalized with probing single-strand DNA. A superconducting quantum interference device (SQUID) ac magnetosusceptometer was employed to detect IMR signals related to the concentration of the target DNA. The results reveal that use of IMR assay had merits such as a high convenience level, e.g. wash-free processes and high sensitivity, down to pM, for DNA detection. (C) 2010 Elsevier B.V. All rights reserved.
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