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標題: Anti-inflammatory neolignans from Piper kadsura
作者: Lin, L.C.
Shen, C.C.
Shen, Y.C.
Tsai, T.H.
關鍵字: chemical-constituents;lignans;schmidtii;acid
Project: Journal of Natural Products
期刊/報告no:: Journal of Natural Products, Volume 69, Issue 5, Page(s) 842-844.
Two new neolignans, piperkadsin A (1) and piperkadsin B (2), as well as 11 known neolignans, three known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of Piper kadsura. The anti-inflammatory activities of these compounds were evaluated. Compounds 1, 2, futoquinol ( 3), piperlactam S (4), and N-p-coumaroyl tyramine (5) showed potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC50 values 4.3 +/- 1.0, 12.2 +/- 3.2, 13.1 +/- 5.3, 7.0 +/- 1.9, and 8.4 +/- 1.3 mu M, respectively.
ISSN: 0163-3864
DOI: 10.1021/np0505521
Appears in Collections:期刊論文

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