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|標題:||Spheroid Formation from Neural Stem Cells on Chitosan Membranes||作者:||Hsu, S.H.
|關鍵字:||Neural stem cells;chitosan;spheroids;peripheral-nerve regeneration;stem/progenitor cells;neurosphere assay;growth-factor;differentiation;proliferation;promoter;behavior;surface;system||Project:||Journal of Medical and Biological Engineering||期刊/報告no：:||Journal of Medical and Biological Engineering, Volume 32, Issue 2, Page(s) 85-90.||摘要:||
This study demonstrates neural stem cells forming neurosphere-like three-dimensional adherent spheroids on chitosan membranes. Their state can be maintained for at least fifteen days, during which period the spheroids increase their size and number. After this period, the neural stem cells start to migrate out of the spheroids, which change in size when the culture period is prolonged. It is believed that the spheroid formation on chitosan can maintain the self-renewal and plasticity of neural stem cells for weeks, with differentiation possibly occurring at a later period. The culture of neural stem cells on certain chitosan membranes can be used to purify neural stem cells from a heterogeneous cell population.
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