Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70365
DC FieldValueLanguage
dc.contributor.authorLiao, P.H.en_US
dc.contributor.authorChen, T.H.en_US
dc.contributor.authorLiao, P.Y.en_US
dc.date2002zh_TW
dc.date.accessioned2014-06-11T05:59:44Z-
dc.date.available2014-06-11T05:59:44Z-
dc.identifier.issn0009-4536zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/70365-
dc.description.abstractThe Ad2 E3-19k protein inhibits the transport of newly synthesized class I MHC molecules to the cell surface, thereby interfering with antigen presentation. The detai Is of the interaction between E3-19k protein and class I MHC molecules have not been well-defined. In this present study, we describe the use of gel filtration HPLC for confirming the binding interaction of two domain proteins, E3-19k and MHC class I antigen, and subsequently the characterization of protein complex by SDS-PAGE. Our results demonstrate the complex formation between Ad2 lumenal E3-19k (108 amino acids, wt 108) and HLA-A*0201 molecule in vitro. Titration experiments will be employed in the future to determine stoichiometry and verify the specific interactions.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of the Chinese Chemical Societyen_US
dc.relation.ispartofseriesJournal of the Chinese Chemical Society, Volume 49, Issue 4, Page(s) 607-610.en_US
dc.subjectcomplex formationen_US
dc.subjectadenovirus E3-19k proteinen_US
dc.subjectmajor histocompatibilityen_US
dc.subjectcomplex (MHC)en_US
dc.subjectHLA-A*0201en_US
dc.subjectnf-kappa-ben_US
dc.subjecte3/19k proteinen_US
dc.subjectescherichia-colien_US
dc.subjectantigenen_US
dc.subjectbindingen_US
dc.subjecttype-2en_US
dc.subjectassociationen_US
dc.subjectactivationen_US
dc.subjectepitopeen_US
dc.subjectpathwayen_US
dc.titleComplex formation between the lumenal domain of adenovirus E3-19k protein and the extracellular domain of class I MHC molecule in vitroen_US
dc.typeJournal Articlezh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
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