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|標題:||Conformational analysis of biphenyl derivatives. I. A novel steric constant from the internal rotation rate of 2,2 '-bis-(N-substituted carbamoylmethyl)biphenyl by means of dynamic NMR||作者:||Lin, G.L.
|關鍵字:||conformational analysis;stereochemistry;steric constant;dynamic NMR;pancreatic cholesterol esterase;carbamate inhibitors;lipase;site||Project:||Journal of the Chinese Chemical Society||期刊/報告no：:||Journal of the Chinese Chemical Society, Volume 47, Issue 3, Page(s) 449-454.||摘要:||
A novel scale of steric substituent constant E-s(D) is defined from the correlation of the logarithms of the internal rotation rate (k(r)) at 393 K with Hancock (E-s(c)) steric constant by means of dynamic NMR. In the inhibition of Pseudomona species lipase by 2,2'-bis-(N-substituted carbamoylmethyl)biphenyls (1-8), the logarithms of bi-molecular rate constants are multiply correlated with both the Taft substituent constant sigma* and E-s(D).
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