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標題: Conformational analysis of biphenyl derivatives. I. A novel steric constant from the internal rotation rate of 2,2 '-bis-(N-substituted carbamoylmethyl)biphenyl by means of dynamic NMR
作者: Lin, G.L.
Hwang, C.I.
Chouhwang, J.Y.
Tsai, H.J.
關鍵字: conformational analysis;stereochemistry;steric constant;dynamic NMR;pancreatic cholesterol esterase;carbamate inhibitors;lipase;site
Project: Journal of the Chinese Chemical Society
期刊/報告no:: Journal of the Chinese Chemical Society, Volume 47, Issue 3, Page(s) 449-454.
A novel scale of steric substituent constant E-s(D) is defined from the correlation of the logarithms of the internal rotation rate (k(r)) at 393 K with Hancock (E-s(c)) steric constant by means of dynamic NMR. In the inhibition of Pseudomona species lipase by 2,2'-bis-(N-substituted carbamoylmethyl)biphenyls (1-8), the logarithms of bi-molecular rate constants are multiply correlated with both the Taft substituent constant sigma* and E-s(D).
ISSN: 0009-4536
Appears in Collections:期刊論文

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