Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70374
DC FieldValueLanguage
dc.contributor.authorLin, G.L.en_US
dc.contributor.authorKao, B.H.en_US
dc.date2000zh_TW
dc.date.accessioned2014-06-11T05:59:44Z-
dc.date.available2014-06-11T05:59:44Z-
dc.identifier.issn0009-4536zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/70374-
dc.description.abstractEpoxy type inhibitors, 3-t-butylphenyl 3-1,2-epoxybutyl ether (1), 3-t-butylphenyl 3-1,2-epoxyhexyl ether (2), and 2-naphthyl 3-1,2-epoxyhexyl ether (3) are synthesized as the active site-directed inhibitors of cholesterol esterase, acetylcholinesterase, and butyrylcholinesterase. All epoxy compounds are characterized as the time-independent inhibitors for all three enzymes from the stopped-time assay. Further, all epoxy compounds are characterized as the competitive inhibitors for all three enzymes from the Lineweavcr-Burk plots. The inhibition constants (K-i) of cholesterol esterase for compounds 1-3 are 320 +/- 40, 190 +/- 20, 130 +/- 20 mu M, respectively. The K-i values of acetylcholinesterase for compounds 1-3 are 490 +/- 20, 141 +/- 5, 200 +/- 30 mu M, respectively. Values of K-i of butyrylcholinesterase for compounds 1-3 are 250 +/- 30, 26 +/- 4, 120 +/- 20 mu M, respectively. Compound 2 is the most potent inhibitor for butyrylcholinesterase probably because the compound mimics most the natural substrate, butyrylcholine.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of the Chinese Chemical Societyen_US
dc.relation.ispartofseriesJournal of the Chinese Chemical Society, Volume 47, Issue 2, Page(s) 397-404.en_US
dc.subjectepoxy inhibitorsen_US
dc.subjectcholesterol esteraseen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectbutyrylcholinesteraseen_US
dc.subjecthuman-serum cholinesteraseen_US
dc.subjectpara-nitrophenylen_US
dc.subjectlipaseen_US
dc.subjectbindingen_US
dc.subjectsiteen_US
dc.subjectaciden_US
dc.subjectraten_US
dc.subjectinactivationen_US
dc.subjectpurificationen_US
dc.subjecthydrolysisen_US
dc.titleEpoxy type inhibitors of cholesterol esterase, acetylcholinesterase, and butyrylcholinesteraseen_US
dc.typeJournal Articlezh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
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