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標題: Influence of dietary supplementation with Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora in hamsters
作者: Wang, C.Y.
Lin, H.T.
Wu, S.C.
關鍵字: Bacillus subtilis;adlay;cholesterol;antioxidant;low-density-lipoprotein;methanolic extracts;dehulled adlay;ldl;oxidation;soybeans;rats;jobi;components;microbiota;natto
Project: Journal of the Science of Food and Agriculture
期刊/報告no:: Journal of the Science of Food and Agriculture, Volume 91, Issue 12, Page(s) 2271-2276.
BACKGROUND: The effects of polished and dehulled Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora were examined in hyperlipidaemic hamsters fed a high-cholesterol diet. RESULTS: Hamsters administered Bacillus-fermented adlay experienced significantly reduced (P < 0.05) serum and hepatic total cholesterol (by 37-43% and 42-49% respectively) and triglyceride (by 22-27% and 30-35% respectively) levels compared with the high-cholesterol group. Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios in serum and increased cholesterol (by 47-52%) and triglyceride (by 40-47%) contents in faeces were also observed. Bacillus-fermented adlay lowered the levels of thiobarbituric acid-reactive substances, thus increasing total antioxidant and superoxide dismutase activities. In particular, polished Bacillus-fermented adlay had satisfactory antioxidant activity, similar to that of commercially available natto. Moreover, hamsters fed Bacillus-fermented adlay harboured greater populations of lactic acid bacteria, few coliforms and little Clostridium perfringens. CONCLUSION: This study has shown that changes in lipid metabolism, antioxidant status and intestinal microflora can be greatly modulated by Bacillus-fermented adlay, suggesting potential novel approaches to the treatment of primary cardiovascular and intestinal diseases. (C) 2011 Society of Chemical Industry
ISSN: 0022-5142
DOI: 10.1002/jsfa.4450
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