Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70520
DC FieldValueLanguage
dc.contributor.authorHsu, K.H.en_US
dc.contributor.authorChen, K.C.en_US
dc.contributor.authorYang, T.Y.en_US
dc.contributor.authorYeh, Y.C.en_US
dc.contributor.authorChou, T.Y.en_US
dc.contributor.authorChen, H.Y.en_US
dc.contributor.authorTsai, C.R.en_US
dc.contributor.authorChen, C.Y.en_US
dc.contributor.authorHsu, C.P.en_US
dc.contributor.authorHsia, J.Y.en_US
dc.contributor.authorChuang, C.Y.en_US
dc.contributor.authorTsai, Y.H.en_US
dc.contributor.authorChen, K.Y.en_US
dc.contributor.authorHuang, M.S.en_US
dc.contributor.authorSu, W.C.en_US
dc.contributor.authorChen, Y.M.en_US
dc.contributor.authorHsiung, C.A.en_US
dc.contributor.authorChang, G.C.en_US
dc.contributor.authorChen, C.J.en_US
dc.contributor.authorYang, P.C.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-11T05:59:56Z-
dc.date.available2014-06-11T05:59:56Z-
dc.identifier.issn1556-0864zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/70520-
dc.description.abstractPurpose: Early lung adenocarcinoma may present with ground-glass opacity (GGO) component in computed tomography (CT) scan. Epidermal growth factor receptor (EGFR) mutation had been reported in patients with lung cancer with GGO patterns. Nevertheless, the correlation between clinical characteristics, CT image patterns, and EGFR mutation status was indeterminate. Methods: Patients with stage I lung adenocarcinoma with tumor lesions less than 3 cm were included and classified into pure GGO, part-solid, and solid patterns by CT scan images. All patients had EGFR mutation test from frozen tumors. Available paraffin-embedded archival tissues were microdissected into three different locations similar to CT images with central and peripheral parts of tumor, and adjacent normal part for EGFR mutation tests. Results: Totally, 162 patients were analyzed, 90 women and 72 men, and 128 nonsmokers. The patients included 35 (21.6%) pure GGO, 41 (25.3%) part-solid, and 86 (53.1%) solid lesions. The EGFR mutation rate was 64.2% (n = 104). Analysis of the correlation between CT image patterns and EGFR mutation, the less GGO ratio had more typical mutation, especially L858R (p = 0.037). In 45 microdissected tumors, the central and peripheral parts had the same EGFR mutation status. In adjacent normal parts, 5 of 32 (15.6%) EGFR mutant patients had identical mutation but none in nonmutant patients. Conclusions: In stage I lung adenocarcinoma, typical mutation, especially L858R was detected more frequent in invasive solid pattern and significantly less in pure GGO pattern. EGFR mutation is an early event in the pathogenesis of lung adenocarcinoma and may facilitate the tumor into aggressive behavior.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Thoracic Oncologyen_US
dc.relation.ispartofseriesJournal of Thoracic Oncology, Volume 6, Issue 6, Page(s) 1066-1072.en_US
dc.relation.urihttp://dx.doi.org/10.1097/JTO.0b013e31821667b0en_US
dc.titleEpidermal Growth Factor Receptor Mutation Status in Stage I Lung Adenocarcinoma with Different Image Patternsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1097/JTO.0b013e31821667b0zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
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