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|標題:||Association of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwan||作者:||Lu, J.J.Y.
|關鍵字:||EBV loads;EBV nuclear antigen-1 (EBNA-1);Epstein-Barr virus (EBV);real-time quantitative polymerase chain reaction (RQ-PCR);systemic;lupus erythematosus (SLE);connective-tissue diseases;altered immune-response;human b-cells;nasopharyngeal carcinoma;rheumatoid-arthritis;peptide immunization;humoral autoimmunity;nuclear antigen-1;antibodies;sera||Project:||Lupus||期刊/報告no：:||Lupus, Volume 16, Issue 3, Page(s) 168-175.||摘要:||
An association between Epstein-Barr virus (EBV) infection and systemic lupus erythematosus (SLE) has been suggested from previous serologic evidence. Since most adults in Taiwan are EBV-infected, seroepiderniologic studies based on standard assays for EBV are unlikely to dissociate SLE patients and control groups. We reexamine this question by using novel methodologies in which IgA anti-EBV-coded nuclear antigens-1 (EBNA-1) and IgG anti-EBV DNase antibodies were analysed by ELISA, and EBV viral loads were detected by real-time quantitative PCR for 93 adult SLE patients and 370 age-, sex- and living place-matched healthy controls in Taiwan. The specificities of antibodies for extractible nuclear antigens were determined by Western blot. Our results show that IgA anti-EBV EBNA I antibodies were detectable in 31.2% SLE patients; but only in 4.1% of controls (odds ratio [OR] = 10.72, 95% confidence interval [Cl] = 5.19-22.35; P < 10(-7)), IgG anti-EBV DNase antibodies were detected in 53.8% SLE patients but only in 12.2% controls (OR = 8.40, 95% CI = 4.87-14.51; P < 10(-7)). EBV DNA was amplifiable from the sera of 41.9% SLE patients but from only 3.24% controls (P < 0.05). A significant association of IgG anti-EBV DNase antibodies with anti-Sm/RNP antibodies was observed (P < 0.005). The higher seroreactivity and higher copy numbers of EBV genome indicated association of EBV infection with SLE in Taiwan.
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