Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70814
DC FieldValueLanguage
dc.contributor.authorLiao, S.L.en_US
dc.contributor.authorKao, T.K.en_US
dc.contributor.authorChen, W.Y.en_US
dc.contributor.authorLin, Y.S.en_US
dc.contributor.authorChen, S.Y.en_US
dc.contributor.authorRaung, S.L.en_US
dc.contributor.authorWu, C.W.en_US
dc.contributor.authorLu, H.C.en_US
dc.contributor.authorChen, C.J.en_US
dc.date2004zh_TW
dc.date.accessioned2014-06-11T06:00:24Z-
dc.date.available2014-06-11T06:00:24Z-
dc.identifier.issn0304-3940zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/70814-
dc.description.abstractTetramethylpyrazine (TMP), which is widely used in the treatment of ischemic stroke by Chinese herbalists, is one of the most important active ingredients of the traditional Chinese herbal medicine, Ligusticum wallichii Franchat (Chung Xiong). However, the mechanism by which TMP protects the brain is still not clear. We examined neuroprotective effects of TMP after transient focal cerebral ischemia using common carotid artery and middle cerebral artery occlusion model in rats and evaluated the involvement of anti-inflammation. TMP administrated intraperitoneally significantly protected the brain against ischemic insult as evidenced by the reduction in infarction volume, preservation of neurons, and decrease in brain edema. TMP markedly reduced cerebral ischemia/reperfusion-induced inflammatory cell activation and proinflammatory mediator production. Moreover, TMP suppressed lipopolysaccharide/interferon-gamma-induced inflammation and prostaglandin E-2 production in cultured glial cells. Our findings suggest that one of neuroprotective effects of TMP against ischemic brain injury might involve its anti-inflammatory potential. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationNeuroscience Lettersen_US
dc.relation.ispartofseriesNeuroscience Letters, Volume 372, Issue 1-2, Page(s) 40-45.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.neulet.2004.09.013en_US
dc.subjectcerebral ischemia/reperfusionen_US
dc.subjectherbsen_US
dc.subjectneuroprotectionen_US
dc.subjecttetramethylpyrazineen_US
dc.subjectfocal cerebral-ischemiaen_US
dc.subjectinfarctionen_US
dc.subjectcoronaryen_US
dc.subjectinfiltrationen_US
dc.subjectinhibitionen_US
dc.titleTetramethylpyrazine reduces ischemic brain injury in ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.neulet.2004.09.013zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
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