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|標題:||Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas||作者:||Fang, H.Y.
|關鍵字:||caspase-14;apoptosis-inducing factor;cisplatin resistance;lung;adenocarcinoma;anti-apoptosis;independent cell-death;dna-damage response;epidermal differentiation;cancer cells;expression;activation;cleavage;survival;smoking;p53||Project:||Oncology Reports||期刊/報告no：:||Oncology Reports, Volume 26, Issue 2, Page(s) 359-369.||摘要:||
Using apoptosis-inducing factor protein as bait in a yeast hybrid assay to screen protein libraries, we identified three proteins that interacted with apoptosis-inducing factor: human homolog of yeast Rad23 protein A (hHR23A), microsomal glutathione S-transferase and caspase-14 (casp-14). In this study, we investigated the expression and function of casp-14 in lung adenocarcinomas (LADC). Our results showed that monoclonal antibodies were specific to casp-14, and that casp-14 was highly expressed in LADC. Casp-14 overexpression correlated with tumor stage, cell differentiation and lymphovascular involvement, suggesting that casp-14 was associated with tumor cell growth and metastatic potential. In vitro, casp-14 interacted with apoptosis-inducing factor, and silencing of casp-14 expression reduced cisplatin resistance. Our data suggest that casp-14 is an anti-apoptotic protein targeting apoptosis-inducing factor and increases cisplatin resistance in LADC cells.
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