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標題: Cytotoxic C-35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica
作者: Chen, C.C.
Wu, J.H.
Yang, N.S.
Chang, J.Y.
Kuo, C.C.
Wang, S.Y.
Kuo, Y.H.
關鍵字: wood oil;abietane diterpenoids;japanese cedar;d. don;components;leaves;sesquiterpenes;constituents;yakusugi;quinone
Project: Organic Letters
期刊/報告no:: Organic Letters, Volume 12, Issue 12, Page(s) 2786-2789.
A novel C-35-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway Is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC50 value of 6.44 +/- 2.23 mu M.
ISSN: 1523-7060
DOI: 10.1021/ol1009027
Appears in Collections:期刊論文

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