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標題: Long range correlation and possible electron conduction through DNA sequences
作者: Wang, S.C.
Li, P.C.
Tseng, H.C.
關鍵字: DNA sequence;long range correlation;conductivity;Saccharomyces;cerevisiae genome;transport
Project: Physica a-Statistical Mechanics and Its Applications
期刊/報告no:: Physica a-Statistical Mechanics and Its Applications, Volume 387, Issue 21, Page(s) 5159-5168.
Long range correlation analysis and charge conductivity investigation are applied to sequences in 16 chromosomes in the Saccharomyces cerevisiae genome. DNA sequence data are analyzed via Hurst's analysis and Detrended Fluctuation Analysis (DFA) analysis. Super diffusive nature of mapping sequences are evident with the measured Hurst exponent H to be around the value of 0.60 for all sequences in the 16 chromosomes. The DFA result is consistent with the result from the Hurst analysis. Tight binding models are applied for the investigation of charge conduction through DNA sequences. The overall averaged transmission coefficients, (T(N))(av), calculated from sixteen chromosomes are shown to be significantly different from values calculated from random as well as periodic sequences. Sequences from the S. cerevisiae genome promise better charge conduction ability than random sequences. Finally, delocalized electronic wave function patterns are also shown through calculations using the tight binging model. Slightly delocalized electronic wavefunctions are seen on sequences in sixteen chromosomes, as compared with those obtained from random sequences on the same eigenenergies. (C) 2008 Elsevier B.V. All rights reserved.
ISSN: 0378-4371
DOI: 10.1016/j.physa.2008.04.029
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