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|標題:||Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model||作者:||Ho, Y.T.
|關鍵字:||Berberine;Human tongue SCC-4 cancer cells;Xenograft transplantation;In vivo;cells;apoptosis;pathway||Project:||Phytomedicine||期刊/報告no：:||Phytomedicine, Volume 16, Issue 9, Page(s) 887-890.||摘要:||
Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10 mg/kg of body weight) and doxorubicin (4 mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4 mg/kg of doxorubicin or with 10 mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10 mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic. (c) 2009 Elsevier GmbH. All rights reserved.
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