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|標題:||Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model||作者:||Su, C.C.
|關鍵字:||curcumin;human lung NCI-H460 cancer cells;xenograft transplantation;in vivo;i clinical-trial;dietary curcumin;mice;chemoprevention;apoptosis;antitumor;products;agent||Project:||Phytotherapy Research||期刊/報告no：:||Phytotherapy Research, Volume 24, Issue 2, Page(s) 189-192.||摘要:||
Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once ever), 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg an 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo. Copyright (C) 2010 John Wiley & Sons, Ltd.
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