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標題: Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model
作者: Su, C.C.
Yang, J.S.
Lu, C.C.
Chiang, J.H.
Wu, C.L.
Lin, J.J.
Lai, K.C.
Hsia, T.C.
Lu, H.F.
Fan, M.J.
Chung, J.G.
關鍵字: curcumin;human lung NCI-H460 cancer cells;xenograft transplantation;in vivo;i clinical-trial;dietary curcumin;mice;chemoprevention;apoptosis;antitumor;products;agent
Project: Phytotherapy Research
期刊/報告no:: Phytotherapy Research, Volume 24, Issue 2, Page(s) 189-192.
Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once ever), 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg an 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo. Copyright (C) 2010 John Wiley & Sons, Ltd.
ISSN: 0951-418X
DOI: 10.1002/ptr.2905
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