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標題: Non-invasive and high-sensitivity scanning detection of magnetic nanoparticles in animals using high-T-c scanning superconducting-quantum-interference-device biosusceptometry
作者: Chieh, J.J.
Hong, C.Y.
關鍵字: parameters;ferritin;iron;coil;mice;tool
Project: Review of Scientific Instruments
期刊/報告no:: Review of Scientific Instruments, Volume 82, Issue 8.
Although magnetic nanoparticles (MNPs) have been widely applied to animals in biomedicine, MNPs within animals should be examined in real time, in vivo, and without bio-damaged possibility to evaluate whether the bio-function of MNPs is valid or to further controls the biomedicinal process because of accompanying complex problems such as MNPs distribution and MNPs biodegradation. The non-invasive and high-sensitivity scanning detection of MNPs in animals using ac susceptometry based on a high-T-c superconducting quantum interference device (SQUID) is presented. The non-invasive results and biopsy results show good agreement, and two gold-standard biomedicine methods, Prussian blue stain and inductively coupled plasma, prove the magnetic results. This confirms that the future clinical diagnosis of bio-functional MNPs could be operated by using scanning SQUID biosusceptometry as conveniently as an ultrasonic probe. (C) 2011 American Institute of Physics. [doi:10.1063/1.3623795]
ISSN: 0034-6748
DOI: 10.1063/1.3623795
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