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|標題:||Non-invasive and high-sensitivity scanning detection of magnetic nanoparticles in animals using high-T-c scanning superconducting-quantum-interference-device biosusceptometry||作者:||Chieh, J.J.
|關鍵字:||parameters;ferritin;iron;coil;mice;tool||Project:||Review of Scientific Instruments||期刊/報告no：:||Review of Scientific Instruments, Volume 82, Issue 8.||摘要:||
Although magnetic nanoparticles (MNPs) have been widely applied to animals in biomedicine, MNPs within animals should be examined in real time, in vivo, and without bio-damaged possibility to evaluate whether the bio-function of MNPs is valid or to further controls the biomedicinal process because of accompanying complex problems such as MNPs distribution and MNPs biodegradation. The non-invasive and high-sensitivity scanning detection of MNPs in animals using ac susceptometry based on a high-T-c superconducting quantum interference device (SQUID) is presented. The non-invasive results and biopsy results show good agreement, and two gold-standard biomedicine methods, Prussian blue stain and inductively coupled plasma, prove the magnetic results. This confirms that the future clinical diagnosis of bio-functional MNPs could be operated by using scanning SQUID biosusceptometry as conveniently as an ultrasonic probe. (C) 2011 American Institute of Physics. [doi:10.1063/1.3623795]
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