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|標題:||A Non-coding RNA of Insect HzNV-1 Virus Establishes Latent Viral Infection through MicroRNA||作者:||Wu, Y.L.
|關鍵字:||non-occluded baculovirus;sequence;cells;apoptosis;genome;gene;dna||Project:||Scientific Reports||期刊/報告no：:||Scientific Reports, Volume 1.||摘要:||
Heliothis zea nudivirus-1 (HzNV-1) is an insect virus previously known as Hz-1 baculovirus. One of its major early genes, hhi1, is responsible for the establishment of productive viral infection; another gene, pag1, which expresses a non-coding RNA, is the only viral transcript detectable during viral latency. Here we showed that this non-coding RNA was further processed into at least two distinct miRNAs, which targeted and degraded hhi1 transcript. This is a result strikingly similar to a recent report that herpes simplex virus produces tightly-regulated latent specific miRNAs to silence its own key early transcripts. Nevertheless, proof for the establishment of viral latency by miRNA is still lacking. We further showed that HzNV-1 latency could be directly induced by pag1-derived miRNAs in cells infected with a pag1-deleted, latency-deficient virus. This result suggests the existence of a novel mechanism, where miRNAs can be functional for the establishment of viral latency.
|Appears in Collections:||期刊論文|
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