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標題: A Non-coding RNA of Insect HzNV-1 Virus Establishes Latent Viral Infection through MicroRNA
作者: Wu, Y.L.
Wu, C.P.
Liu, C.Y.Y.
Hsu, P.W.C.
Wu, E.C.
Chao, Y.C.
關鍵字: non-occluded baculovirus;sequence;cells;apoptosis;genome;gene;dna
Project: Scientific Reports
期刊/報告no:: Scientific Reports, Volume 1.
Heliothis zea nudivirus-1 (HzNV-1) is an insect virus previously known as Hz-1 baculovirus. One of its major early genes, hhi1, is responsible for the establishment of productive viral infection; another gene, pag1, which expresses a non-coding RNA, is the only viral transcript detectable during viral latency. Here we showed that this non-coding RNA was further processed into at least two distinct miRNAs, which targeted and degraded hhi1 transcript. This is a result strikingly similar to a recent report that herpes simplex virus produces tightly-regulated latent specific miRNAs to silence its own key early transcripts. Nevertheless, proof for the establishment of viral latency by miRNA is still lacking. We further showed that HzNV-1 latency could be directly induced by pag1-derived miRNAs in cells infected with a pag1-deleted, latency-deficient virus. This result suggests the existence of a novel mechanism, where miRNAs can be functional for the establishment of viral latency.
ISSN: 2045-2322
DOI: 10.1038/srep00060
Appears in Collections:期刊論文

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