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標題: Prothrombin time tests on a microfluidic disc analyzer
作者: Shih, C.H.
Lu, C.H.
Wu, J.H.
Lin, C.H.
Wang, J.M.
Lin, C.Y.
關鍵字: Prothrombin time test;International normalized ratio;Microfluidic disc;analyzer;Centrifugation;Mixing;oral anticoagulant-therapy;whole-blood;centrifugal microfluidics;clinical effectiveness;coagulation time;device;management;warfarin;platform;sedimentation
Project: Sensors and Actuators B-Chemical
期刊/報告no:: Sensors and Actuators B-Chemical, Volume 161, Issue 1, Page(s) 1184-1190.
Prothrombin time test is used to measure the time required for blood to coagulate and is essential for monitoring appropriate drug dosing in patients taking oral anti-coagulants. To reduce the costs of reagents and improve the stability of tests, a microfluidic disc analyzer (MDA) has been developed. This analyzer can process small volumes of liquid samples (less than 10 mu l total volume required) and performs effective and fast mixing (within one second) under centrifugation. During the mixing process, two reactants can also maintain a constant ratio of flowrate. One hundred and one clinical samples were tested by the MDA and the Sysmex CA1500 coagulation analyzer, which was frequently used as a reference machine, for comparison. The test results from these two instruments show good correlation and agreement. (c) 2011 Elsevier B.V. All rights reserved.
ISSN: 0925-4005
DOI: 10.1016/j.snb.2011.11.025
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