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標題: Synthesis of Allenes via Nickel-Catalyzed Cross-Coupling Reaction of Propargylic Bromides with Grignard Reagents
作者: Li, Q.H.
Gau, H.M.
關鍵字: allenes;nickel;propargylic bromide;Grignard reagent;cross-coupling;one-pot synthesis;hydride-transfer reaction;axially chiral allenes;substituted allenes;1,3-disubstituted allenes;organic-synthesis;enantioselective synthesis;stereospecific synthesis;asymmetric-synthesis;general-route
Project: Synlett
期刊/報告no:: Synlett, Issue 5, Page(s) 747-750.
We describe a convenient method for the synthesis of terminal allenes from cross-coupling of propargylic bromide with Grignard reagent. The reaction of propargylic bromide with 1.2 equivalents of Grignard reagent mediated by Ni(acac)(2) (2 mol%) and Ph3P (4 mol%) in THF may produce terminal allenes in good yields and high regioselectivities at room temperature.
ISSN: 0936-5214
DOI: 10.1055/s-0031-1290365
Appears in Collections:期刊論文

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