Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction

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Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71441

標題:	Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction
作者:	Chang, C.Y. Yang, T.K.
關鍵字:	angiotensin-converting enzyme;fermenting bakers-yeast;diastereoselective synthesis;pharmacological properties;stereochemical;control;therapeutic efficacy;microbial reduction;derivatives;esters;hydrogenation
Project:	Tetrahedron-Asymmetry
期刊/報告no：:	Tetrahedron-Asymmetry, Volume 14, Issue 15, Page(s) 2239-2245.
摘要:	An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3'S)-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2,4-dioxobutyric acid ethyl ester 6b employing baker's yeast as the reductive catalyst. (C) 2003 Elsevier Ltd. All rights reserved.
URI:	http://hdl.handle.net/11455/71441
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(03)00453-1
Appears in Collections:	期刊論文

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