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標題: Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction
作者: Chang, C.Y.
Yang, T.K.
關鍵字: angiotensin-converting enzyme;fermenting bakers-yeast;diastereoselective synthesis;pharmacological properties;stereochemical;control;therapeutic efficacy;microbial reduction;derivatives;esters;hydrogenation
Project: Tetrahedron-Asymmetry
期刊/報告no:: Tetrahedron-Asymmetry, Volume 14, Issue 15, Page(s) 2239-2245.
An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3'S)-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2,4-dioxobutyric acid ethyl ester 6b employing baker's yeast as the reductive catalyst. (C) 2003 Elsevier Ltd. All rights reserved.
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00453-1
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