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標題: Antibiotic susceptibility and prevalence of erythromycin ribosomal methylase gene, erm(B) in Streptococcus spp
作者: Hung, S.W.
Wang, S.L.
Tu, C.Y.
Tsai, Y.C.
Chuang, S.T.
Shieh, M.T.
Liu, P.C.
Wang, W.S.
關鍵字: erm(B) gene;Streptococcus spp.;antibiotic susceptibility;erythromycin;macrolide-resistant strains;in-vitro activity;genotypic;characterization;molecular characterization;antimicrobial resistance;southern taiwan;group-a;pneumoniae;mef(a);determinants
Project: Veterinary Journal
期刊/報告no:: Veterinary Journal, Volume 176, Issue 2, Page(s) 197-204.
The aim of this study was to investigate drug resistance and the genetic relatedness of erythromycin-resistant Streptococcus spp. from different animals and humans in Taiwan. Cumulatively, 248 isolates were collected from 15 animal species and human patients and the susceptibilities of the isolates to six antimicrobial agents including azithromycin (AZI), clarithromycin (CLAR), erythromycin (ERY), spiramycin (SPIR), amoxicillin (AMO), and enrofloxacin (ENRO) were determined by the agar dilution method. The results indicated that resistance among the 248 strains was highest for SPIR, followed by ENRO, CLAR, ERY, AZI, and AMO. The most common resistotypes of the isolates from mammals and aquatic animals were AZI-CLAR-ERY-SPIR (27.5%) and SPIR (55.1%), respectively. The presence of ERY-resistant genes was confirmed by PCR. The erm gene was amplified from 28 isolates (20.61%) by PCR for further investigation. The predominant erm gene in the ERY-resistant isolates was the erm(B) gene. The phylogenetic analysis of the erm(B) gene results indicated that there was a close genetic relationship among all the strains but the genotypic clusters did not show clear segregation of the isolates according to the source or region. (C) 2007 Elsevier Ltd. All rights reserved.
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2007.02.008
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