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|標題:||Antimicrobial susceptibility, plasmid profiles and haemocin activities of Avibacterium paragallinarum strains||作者:||Hsu, Y.M.
|關鍵字:||avibacterium paragallinarum;antimicrobial susceptibility;haemocin;pYMH5;complete nucleotide-sequence;haemophilus-paragallinarum;hemophilus-paragallinarum;shigella-flexneri;psi-blast;vacb gene;rnase-r;resistance;virulence;bacteria||Project:||Veterinary Microbiology||期刊/報告no：:||Veterinary Microbiology, Volume 124, Issue 3-4, Page(s) 209-218.||摘要:||
In this study, 18 Avibacterium paragallinarum isolates collected in Taiwan from 1990 to 2003 were serotyped and tested for resistance to antimicrobial agents. Serotyping revealed that 13 isolates were Page serovar A and 5 isolates were Page serovar C. More than 75% of the isolates were resistant to neomycin, streptomycin and erythromycin. The most common resistance pattern (15 isolates, 83.3%) was neomycin-streptomycin. Furthermore, 88.9% of the isolates were resistant to two or more antibiotics. About 72% of isolates contained plasmids (pYMH5 and/or pA14). Plasmid pYMH5 encoded functional streptomycin, sulfonamide, kanamycin and neomycin resistance genes and revealed significant homology to a broad host-range plasmid, pLS88. Plasmid pA14 encoded a putative Mg1A protein and RNase II, both of which might be associated with virulence. Furthermore, seven isolates showed haemocin activity. Plasmid pYMH5 is the first multidrug-resistance plasmid reported in A. paragallinarum and it may facilitate the spread of antibiotic-resistance genes between bacteria. The putative virulence plasmid pA14 and haemocin-like activity in A. paragallinarum indicate two possible mechanisms which might be responsible for the pathogenesis. (c) 2007 Elsevier B.V. All rights reserved.
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