Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71564
DC FieldValueLanguage
dc.contributor.authorLee, M.S.en_US
dc.contributor.authorDeng, M.C.en_US
dc.contributor.authorLin, Y.J.en_US
dc.contributor.authorChang, C.Y.en_US
dc.contributor.authorShieh, H.K.en_US
dc.contributor.authorShiau, J.Z.en_US
dc.contributor.authorHuang, C.C.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-11T06:01:57Z-
dc.date.available2014-06-11T06:01:57Z-
dc.identifier.issn0378-1135zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/71564-
dc.description.abstractIn 2003, an avian influenza (AI) virus of H5N1 subtype (A/Duck/China/E319-2/03; Dk/CHN/E319-2/03) was isolated from a smuggled duck in Kinmen Island of Taiwan. Phylogenetic analysis and pairwise comparison of nucleotide and amino acid sequences revealed that the virus displayed high similarity to the H5N1 viruses circulating in Asia during 2004 and 2005. The hemagglutinin (HA) protein of the virus contained multiple basic amino acid residues (-RERRRKR-) adjacent to the cleavage site between the HA1 and HA2 domains, showing the highly pathogenic (HP) characteristics. The HP phenotype was confirmed by experimental infection of chickens, which led up to 100% mortality within 24-72 h postinfection. The virus replicated equally well in the majority of organs of the infected chickens with titers ranging from 10(7.5) to 10(4.7) 50% embryo lethal dose (ELD50) per gram of tissue. In a mouse model the virus exhibits low pathogenic characteristics with a lethal infection observed only after applying high inoculating dose (>= 10(7.6) ELD50) of the virus. The infectious virus particles were recovered only from the pulmonary system including trachea and lungs. Our study suggests that ducks infected with H5N1 AIV of HPAI pathotype showing no disease signs can carry the virus silently and that bird smuggling represent a serious risk for H5N1 HPAI transmission. (c) 2007 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationVeterinary Microbiologyen_US
dc.relation.ispartofseriesVeterinary Microbiology, Volume 124, Issue 3-4, Page(s) 193-201.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.vetmic.2007.04.021en_US
dc.subjecthighly pathogenic avian influenzaen_US
dc.subjectH5N1en_US
dc.subjectsurveillanceen_US
dc.subjectinterspeciesen_US
dc.subjecttransmissionen_US
dc.subjectantiviral cytokine responsesen_US
dc.subjecta virusesen_US
dc.subjecthong-kongen_US
dc.subjecthuman-diseaseen_US
dc.subjectamino-aciden_US
dc.subjectpathogenicityen_US
dc.subjecthumansen_US
dc.subjectmiceen_US
dc.subjectpathogenesisen_US
dc.subjectsequenceen_US
dc.titleCharacterization of an H5N1 avian influenza virus from Taiwanen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.vetmic.2007.04.021zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
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