Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71589
DC FieldValueLanguage
dc.contributor.authorChen, W.Y.en_US
dc.contributor.author毛嘉洪zh_TW
dc.contributor.authorChen, C.J.en_US
dc.contributor.authorLiao, J.W.en_US
dc.contributor.authorMao, F.C.en_US
dc.contributor.author廖俊旺zh_TW
dc.date2009zh_TW
dc.date.accessioned2014-06-11T06:02:02Z-
dc.date.available2014-06-11T06:02:02Z-
dc.identifier.issn0024-3205zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/71589-
dc.description.abstractAims: Oxidative stress is involved in cholestasis-induced hepatic damage. Therefore, antioxidant therapy is a recommended therapeutic strategy. Studies have illustrated that chromium can enhance antioxidative capacity leading to a resolution of oxidative stress. The aim of this study was to assess whether chromium has protective effects against cholestasis-related liver damage. Main methods: Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Rats were randomly divided into four groups. Control and BDL groups were subjected to sham and BDL operation, respectively, and were supplemented with placebo for 3 weeks. The BDL-post Cr group was supplemented with chromium chloride for 3 weeks after BDL operation. The BDL-pre Cr group was supplemented with chromium chloride for 6 weeks starting from 3 weeks before BDL operation. Key findings: In comparison with the control group, the BDL group showed hepatic damage as evidenced by elevation in serum biochemicals, ductular reaction, and fibrosis. These pathophysiological changes were attenuated in the BDL-Pre Cr and BDL-Post Cr groups. However, there was no significant difference between these two groups. The anti-fibrotic effect of chromium was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of transforming growth factor beta 1 (TGF-beta 1). In addition, chromium effectively attenuated BDL-induced hepatic oxidative stress. Significance: The data indicate that chromium attenuates BIDL-induced cholestatic liver injury, bile duct proliferation, and fibrosis. The hepatoprotective effect of chromium is associated with antioxidative potential. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationLife Sciencesen_US
dc.relation.ispartofseriesLife Sciences, Volume 84, Issue 17-18, Page(s) 606-614.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.lfs.2009.02.003en_US
dc.subjectCholestasisen_US
dc.subjectChromiumen_US
dc.subjectHepatotoxicityen_US
dc.subjectOxidative stressen_US
dc.subjecttype-2 diabetes-mellitusen_US
dc.subjectduct-ligated raten_US
dc.subjectlipid-peroxidationen_US
dc.subjectliveren_US
dc.subjectfibrosisen_US
dc.subjectmatrix metalloproteinasesen_US
dc.subjectcarbon-tetrachlorideen_US
dc.subjectoxidativeen_US
dc.subjectstressen_US
dc.subjecttrace quantitiesen_US
dc.subjectsupplementationen_US
dc.subjectglucoseen_US
dc.titleChromium attenuates hepatic damage in a rat model of chronic cholestasisen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.lfs.2009.02.003zh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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