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|標題:||Chromium attenuates hepatic damage in a rat model of chronic cholestasis||作者:||Chen, W.Y.
|關鍵字:||Cholestasis;Chromium;Hepatotoxicity;Oxidative stress;type-2 diabetes-mellitus;duct-ligated rat;lipid-peroxidation;liver;fibrosis;matrix metalloproteinases;carbon-tetrachloride;oxidative;stress;trace quantities;supplementation;glucose||Project:||Life Sciences||期刊/報告no：:||Life Sciences, Volume 84, Issue 17-18, Page(s) 606-614.||摘要:||
Aims: Oxidative stress is involved in cholestasis-induced hepatic damage. Therefore, antioxidant therapy is a recommended therapeutic strategy. Studies have illustrated that chromium can enhance antioxidative capacity leading to a resolution of oxidative stress. The aim of this study was to assess whether chromium has protective effects against cholestasis-related liver damage. Main methods: Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Rats were randomly divided into four groups. Control and BDL groups were subjected to sham and BDL operation, respectively, and were supplemented with placebo for 3 weeks. The BDL-post Cr group was supplemented with chromium chloride for 3 weeks after BDL operation. The BDL-pre Cr group was supplemented with chromium chloride for 6 weeks starting from 3 weeks before BDL operation. Key findings: In comparison with the control group, the BDL group showed hepatic damage as evidenced by elevation in serum biochemicals, ductular reaction, and fibrosis. These pathophysiological changes were attenuated in the BDL-Pre Cr and BDL-Post Cr groups. However, there was no significant difference between these two groups. The anti-fibrotic effect of chromium was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of transforming growth factor beta 1 (TGF-beta 1). In addition, chromium effectively attenuated BDL-induced hepatic oxidative stress. Significance: The data indicate that chromium attenuates BIDL-induced cholestatic liver injury, bile duct proliferation, and fibrosis. The hepatoprotective effect of chromium is associated with antioxidative potential. (C) 2009 Elsevier Inc. All rights reserved.
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