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標題: Chronic Users of Supraphysiological Doses of Anabolic Androgenic Steroids Develop Hematological and Serum Lipoprotein Profiles That Are Characteristic of High Cardiovascular Risk
作者: Alex Souto Maior
Charlos Belchior
Rogerio Costa Sanches
Tiago Oliveira da Silva
Tomas Leonelli
Paulo Adriano Schwingel
Roberto Simao
Moacir Marocolo
Jose Hamilton Matheus Nascimento
關鍵字: Anabolic androgenic steroids;Atherogenesis;Lipoprotein;Submaximal exercise test
出版社: Taichung, Taiwan :Graduate Institute of Sports & Health Management, National Chung Hsing University
Project: International Journal of Sport and Exercise Science, Volume 3, Issue 2, Page(s) 27-36.
The purpose of this study was to evaluate the effect of long-term anabolic androgenic steroids (AAS) use on the
hematological and lipoprotein profile of young men practicing sports at fitness centers. Twenty-two male subjects were
divided in two groups: AAS (n = 11; 27.3 ± 4.5 years; 85.1 ± 6.8 kg; 174 ± 5.5 cm) and control (n = 11; 24.7 ± 3.6 years;
81.7 ± 7.6 kg; 178.5 ± 6.5 cm). The hemodynamic response, metabolic profile (blood glucose and lactate) and serum
lipoprotein levels were measured prior to, during, and after a submaximal exercise test on a cycloergometer. Blood
samples were obtained before the exercise test to determine the hematological profile (white and red cells). The
hemodynamic response showed no statistically difference between groups before, during, or after submaximal exercise
test. Hemoglobin, hematocrit, erythrocytes, leucocytes and monocytes were significantly higher (p < 0.05) in AAS users
compared to control subjects. HDL-cholesterol level was significantly lower, whereas triglycerides levels,
LDL-cholesterol level and the LDL-c/HDL-c ratio were significantly higher in the AAS group. Blood glucose and
lactate levels were significantly higher in the AAS users after submaximal exercise test. In conclusion, young men
practicing sports at fitness centers who are AAS users exhibit proatherogenic and prothrombotic profile, and premature
metabolic disturb in despite of regular physical activity.
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