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標題: First detection of the Africa/Caribbean/Latin American subtype of Culex flavivirus in Asian country, Taiwan
關鍵字: Culex flavivirus;Insect-only flavivirus;Culex mosquitoes
Project: Comparative Immunology, Microbiology and Infectious Diseases, Volume 36, Issue 4, Page(s) 387-396.
Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insectinsect-specific flavivirusesthat can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathicAfrica/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries,and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools wereCxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closelyrelated to the Africa/Caribbean/Latin American subtype, but form an independent cluster. Inthe cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and causedcell–cell fusion that might be associated with a unique glycine residue at position 117 withinthe envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype.This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV hasbeen identified in an Asian country and grouped into a novel cluster.
DOI: 10.1016/j.cimid.2013.02.001
Appears in Collections:微生物暨公共衛生學研究所

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