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標題: Synthesis of a Photostable Near-Infrared-Absorbing Photosensitizer for Selective Photodamage to Cancer Cells
作者: Hsieh, Tung-Sheng
Wu, Jhen-Yi
Chang, Cheng-Chung
關鍵字: near infrared;phenothiazinium;photodamage;photosensitizers;reactive oxygen species;Cell Line;Fibroblasts;HeLa Cells;Humans;Oxidation-Reduction;Phenothiazines;Photochemical Processes;Photochemotherapy;Photosensitizing Agents;Reactive Oxygen Species;Singlet Oxygen
Project: Chemistry - A European Journal, Volume 20, Issue 31, Page(s) 9709-9715.
A new class of near-infrared (NIR)-absorptive (>900 nm) photosensitizer based on a phenothiazinium scaffold is reported. The stable solid compound, o-DAP, the oxidative form of 3,7-bis(4-methylaminophenyl)-10H-phenothiazine, can generate reactive oxygen species (ROS, singlet oxygen and superoxide) under appropriate irradiation conditions. After biologically evaluating the intracellular uptake, localization, and phototoxicity of this compound, it was concluded that o-DAP is photostable and a potential selective photodynamic therapy (PDT) agent under either NIR or white light irradiation because its photodamage is more efficient in cancer cells than in normal cells and is without significant dark toxicity. This is very rare for photosensitizers in PDT applications.
ISSN: 09476539
DOI: 10.1002/chem.201402285
Appears in Collections:生醫工程研究所

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