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|標題:||Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation||作者:||Chen, Wen-Ying
|關鍵字:||Acute lung injury;Akt;LPS;MIP-2;MMP-9;Rutin;Acute Lung Injury;Animals;Bronchoalveolar Lavage Fluid;Chemokine CXCL2;Down-Regulation;Lipopolysaccharides;Lung;Matrix Metalloproteinase 9;Mice;Neutrophil Infiltration;Phosphorylation;Protective Agents;Proto-Oncogene Proteins c-akt;Rutin||Project:||International Immunopharmacology, Volume 22, Issue 2, Page(s) 409-413.||摘要:||
Lipopolysaccharide (LPS), also called endotoxin, is the important pathogen of acute lung injury (ALI), which is a clinical syndrome that still lacks effective therapeutic medicine. Rutin belongs to vitamin P and possesses various beneficial effects. In this study, we investigate the potential protective effects and the mechanisms of rutin on LPS-induced ALI. Pre-administration with rutin inhibited LPS-induced arterial blood gas exchange and neutrophils infiltration in the lungs. LPS-induced expression of macrophage inflammatory protein (MIP)-2 and activation of matrix metalloproteinase (MMP)-9 were suppressed by rutin. In addition, the inhibitory concentration of rutin on phosphorylation of Akt was similar as MIP-2 expression and MMP-9 activation. In conclusion, rutin is a potential protective agent for ALI via suppressing the blood gas exchange and neutrophil infiltration. The mechanism of rutin is down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation.
|Appears in Collections:||獸醫學系所|
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