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標題: | Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity | 作者: | Li, Shiming Lin, Yi-Chin Ho, Chi-Tang Lin, Ping-Yi Suzawa, Michiko Wang, Hsin-Chieh Chu, Ching-Liang Chen, Der-Yuan Lin, Chi-Chen |
關鍵字: | Citrus;Contact hypersensitivity (CHS);Dendritic cells;Peels;T cells;Animals;Bone Marrow Cells;Cell Differentiation;Cells, Cultured;Cytokines;Dendritic Cells;Dermatitis, Allergic Contact;Dinitrofluorobenzene;Female;Haptens;Immunologic Factors;Lipopolysaccharides;Mice, Inbred C57BL;Mitogen-Activated Protein Kinases;NF-kappa B;Phagocytosis;Phytotherapy;Plant Preparations;T-Lymphocytes;Citrus | Project: | International immunopharmacology, Volume 20, Issue 1, Page(s) 12-23. | 摘要: | It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC. |
URI: | http://hdl.handle.net/11455/86426 | ISSN: | 1878-1705 | DOI: | 10.1016/j.intimp.2014.02.005 |
Appears in Collections: | 生物醫學研究所 |
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