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標題: Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity
作者: Li, Shiming
Lin, Yi-Chin
Ho, Chi-Tang
Lin, Ping-Yi
Suzawa, Michiko
Wang, Hsin-Chieh
Chu, Ching-Liang
Chen, Der-Yuan
Lin, Chi-Chen
關鍵字: Citrus;Contact hypersensitivity (CHS);Dendritic cells;Peels;T cells;Animals;Bone Marrow Cells;Cell Differentiation;Cells, Cultured;Cytokines;Dendritic Cells;Dermatitis, Allergic Contact;Dinitrofluorobenzene;Female;Haptens;Immunologic Factors;Lipopolysaccharides;Mice, Inbred C57BL;Mitogen-Activated Protein Kinases;NF-kappa B;Phagocytosis;Phytotherapy;Plant Preparations;T-Lymphocytes;Citrus
Project: International immunopharmacology, Volume 20, Issue 1, Page(s) 12-23.
It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC.
ISSN: 1878-1705
DOI: 10.1016/j.intimp.2014.02.005
Appears in Collections:生物醫學研究所

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