Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/86428
DC FieldValueLanguage
dc.contributor.authorLin, Chi-Chenzh_TW
dc.contributor.authorChu, Ching-Liangzh_TW
dc.contributor.authorNg, Chin-Shengzh_TW
dc.contributor.authorLin, Ching-Yenzh_TW
dc.contributor.authorChen, Der-Yuanzh_TW
dc.contributor.authorPan, I-Hongzh_TW
dc.contributor.authorHuang, Kao-Jeanzh_TW
dc.date2014-05-
dc.date.accessioned2015-08-04T03:33:59Z-
dc.date.available2015-08-04T03:33:59Z-
dc.identifier.issn2042-650Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/86428-
dc.description.abstractDietary compounds in fruits and vegetables have been shown to exert many biological activities. In addition to antioxidant effects, a number of flavonoids are able to modulate inflammatory responses. Here, we demonstrated that phloretin (PT), a natural dihydrochalcone found in many fruits, suppressed the activation and function of mouse dendritic cells (DCs). Phloretin disturbed the multiple intracellular signaling pathways in DCs induced by the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPS), including ROS, MAPKs (ERK, JNK, p38 MAPK), and NF-κB, and thereby reducing the production of inflammatory cytokines and chemokines. Phloretin also effectively suppressed the activation of DCs treated with different dosages of LPS or various TLR agonists. The LPS-induced DC maturation was attenuated by phloretin because the expression levels of the MHC class II and the co-stimulatory molecules were down-regulated, which then inhibited the LPS-stimulating DCs and the subsequent naïve T cell activation in a mixed lymphocyte reaction. Moreover, in vivo administration of phloretin suppressed the phenotypic maturation of the LPS-challenged splenic DCs and decreased the IFN-γ production from the activated CD4 T cells. Thus, we suggest that phloretin may potentially be an immunomodulator by impairing the activation and function of DCs and phloretin-contained fruits may be helpful in the improvement of inflammation and autoimmune diseases.zh_TW
dc.language.isoenzh_TW
dc.relationFood & function, Volume 5, Issue 5, Page(s) 997-1006.zh_TW
dc.subjectAnimalszh_TW
dc.subjectCells, Culturedzh_TW
dc.subjectCytokineszh_TW
dc.subjectDendritic Cellszh_TW
dc.subjectImmunologic Factorszh_TW
dc.subjectMicezh_TW
dc.subjectMice, Inbred C57BLzh_TW
dc.subjectPhloretinzh_TW
dc.subjectT-Lymphocyteszh_TW
dc.subjectToll-Like Receptor 4zh_TW
dc.titleImmunomodulation of phloretin by impairing dendritic cell activation and functionzh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1039/c3fo60548ezh_TW
item.openairetypeJournal Article-
item.fulltextwith fulltext-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
Appears in Collections:生物醫學研究所
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