Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/86432
DC FieldValueLanguage
dc.contributor.authorWu, Chieh-Shanzh_TW
dc.contributor.authorChen, Gwo-Shingzh_TW
dc.contributor.authorLin, Ping-Yizh_TW
dc.contributor.authorPan, I-Hongzh_TW
dc.contributor.authorWang, San-Tangzh_TW
dc.contributor.authorLin, Sheng Haozh_TW
dc.contributor.authorYu, Hsin-Suzh_TW
dc.contributor.authorLin, Chi-Chenzh_TW
dc.date2014-
dc.date.accessioned2015-08-04T03:37:50Z-
dc.date.available2015-08-04T03:37:50Z-
dc.identifier.issn1044-5498zh_TW
dc.identifier.issn1557-7430zh_TW
dc.identifier.issn1557-7430zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/86432-
dc.description.abstractPrevious studies suggest that tazarotene, a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis. However, the detailed molecular mechanisms underlying the anti-tumor activity of tazarotene are poorly understood. This study aims at investigating the molecular mechanisms of tazarotene-induced apoptosis in human BCC cells. Our results are the first to demonstrate that tazarotene induces mitochondria-dependent cleavage of caspase-9 and -3 and PARP in BCC cells by producing reactive oxygen species (ROS) and activating caspase-8 through both ROS and death receptor signaling. These events are accompanied by a decrease in BCL-2 and BCL-xl anti-apoptotic proteins as well as by survivin and XIAP, two IAP family members. Furthermore, our results presented for the first time that tazarotene triggers a convergence of the intrinsic and extrinsic apoptotic pathways via the caspase-8-truncated Bid signaling pathway. Collectively, these data provide insights into the molecular mechanisms underlying tazarotene-induced apoptosis in human BCC cells, suggesting that this compound is a potential anti-skin cancer drug.zh_TW
dc.language.isoenzh_TW
dc.relationDNA and Cell Biology, Volume 33, Issue 10, Page(s) 652-666.zh_TW
dc.subjectApoptosiszh_TW
dc.subjectBH3 Interacting Domain Death Agonist Proteinzh_TW
dc.subjectCarcinoma, Basal Cellzh_TW
dc.subjectCaspase 3zh_TW
dc.subjectCaspase 8zh_TW
dc.subjectCaspase 9zh_TW
dc.subjectCell Line, Tumorzh_TW
dc.subjectCell Proliferationzh_TW
dc.subjectCell Survivalzh_TW
dc.subjectCytochromes czh_TW
dc.subjectDown-Regulationzh_TW
dc.subjectEnzyme Activationzh_TW
dc.subjectFas-Associated Death Domain Proteinzh_TW
dc.subjectG1 Phase Cell Cycle Checkpointszh_TW
dc.subjectHumanszh_TW
dc.subjectIn Situ Nick-End Labelingzh_TW
dc.subjectInhibitor of Apoptosis Proteinszh_TW
dc.subjectKeratolytic Agentszh_TW
dc.subjectMembrane Potential, Mitochondrialzh_TW
dc.subjectMitochondriazh_TW
dc.subjectNicotinic Acidszh_TW
dc.subjectPoly(ADP-ribose) Polymeraseszh_TW
dc.subjectProto-Oncogene Proteins c-bcl-2zh_TW
dc.subjectRNA Interferencezh_TW
dc.subjectRNA, Small Interferingzh_TW
dc.subjectReactive Oxygen Specieszh_TW
dc.subjectReceptors, Death Domainzh_TW
dc.subjectSignal Transductionzh_TW
dc.subjectSkin Neoplasmszh_TW
dc.subjectX-Linked Inhibitor of Apoptosis Proteinzh_TW
dc.subjectbcl-X Proteinzh_TW
dc.titleTazarotene Induces Apoptosis in Human Basal Cell Carcinoma via Activation of Caspase-8/t-Bid and the Reactive Oxygen Species-Dependent Mitochondrial Pathwayzh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1089/dna.2014.2366zh_TW
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
Appears in Collections:生物醫學研究所
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