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http://hdl.handle.net/11455/86456| 標題: | All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation | 作者: | Lin, Eugene Chen, Mei-Chih Huang, Chih-Yang Hsu, Shih-Lan Huang, William J. Lin, Mao-Sheng Wu, Jungle Chi-Hsiang Lin, Ho |
Project: | Cellular Physiology and Biochemistry, Volume 33, Issue 6, Page(s) 1620-1630. | 摘要: | All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells. It has been indicated that cyclin-dependent kinase 5 (Cdk5) activity can be affected by ATRA treatment. Our previous results demonstrate the involvement of Cdk5 in the fate of prostate cancer cells. The purpose of this study is to examine whether Cdk5 is involved in ATRA-induced growth arrest of the castration-resistant cancer cell line DU145 through up-regulating Cdk inhibitor protein, p27. |
URI: | http://hdl.handle.net/11455/86456 | ISSN: | 1421-9778 1015-8987 1421-9778 |
DOI: | 10.1159/000358724 |
| Appears in Collections: | 生命科學系所 |
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| 2015-3-6-1-2-1.pdf | 918.66 kB | Adobe PDF | This file is only available in the university internal network Request a copy |
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