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|標題:||All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation||作者:||Lin, Eugene
Huang, William J.
Wu, Jungle Chi-Hsiang
|Project:||Cellular Physiology and Biochemistry, Volume 33, Issue 6, Page(s) 1620-1630.||摘要:||
All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells. It has been indicated that cyclin-dependent kinase 5 (Cdk5) activity can be affected by ATRA treatment. Our previous results demonstrate the involvement of Cdk5 in the fate of prostate cancer cells. The purpose of this study is to examine whether Cdk5 is involved in ATRA-induced growth arrest of the castration-resistant cancer cell line DU145 through up-regulating Cdk inhibitor protein, p27.
|Appears in Collections:||生命科學系所|
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