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標題: All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation
作者: Lin, Eugene
Chen, Mei-Chih
Huang, Chih-Yang
Hsu, Shih-Lan
Huang, William J.
Lin, Mao-Sheng
Wu, Jungle Chi-Hsiang
Lin, Ho
Project: Cellular Physiology and Biochemistry, Volume 33, Issue 6, Page(s) 1620-1630.
All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells. It has been indicated that cyclin-dependent kinase 5 (Cdk5) activity can be affected by ATRA treatment. Our previous results demonstrate the involvement of Cdk5 in the fate of prostate cancer cells. The purpose of this study is to examine whether Cdk5 is involved in ATRA-induced growth arrest of the castration-resistant cancer cell line DU145 through up-regulating Cdk inhibitor protein, p27.
ISSN: 1421-9778
DOI: 10.1159/000358724
Appears in Collections:生命科學系所

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