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標題: Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice
作者: Chen, H-L
Tung, Y-T
Tsai, C-L
Lai, C-W
Lai, Z-L
Tsai, H-C
Lin, Y-L
Wang, C-H
Chen, C-M
關鍵字: Animals;Basal Metabolism;Biological Markers;Blotting, Western;Cultured Milk Products;Disease Models, Animal;Energy Metabolism;Gene Expression Regulation;Lipid Metabolism;Liver;Mice;Mice, Knockout;Mice, Obese;Non-alcoholic Fatty Liver Disease;Organ Size;Receptors, Leptin;Signal Transduction;Sterol Regulatory Element Binding Protein 1
Project: International Journal of Obesity, Volume 38, Issue 9, Page(s) 1172-1179.
Fatty liver disease is commonly associated with obesity, insulin resistance and diabetes. Severe fatty liver is sometimes accompanied by steatohepatitis and may lead to the development of hepatocellular carcinoma. At present, there is no effective treatment for non-alcoholic fatty liver disease (NAFLD); thus, recent investigations have focused on developing effective therapeutics to treat this condition. This study aimed to evaluate the effects of kefir on the hepatic lipid metabolism of ob/ob mice, which are commonly used to model fatty liver disease.
ISSN: 0307-0565
DOI: 10.1038/ijo.2013.236
Appears in Collections:生命科學系所

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