Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/86563
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dc.contributor.authorLiu, Z.-C.zh_TW
dc.contributor.authorXie, Y.-L.zh_TW
dc.contributor.authorChang, C.-J.zh_TW
dc.contributor.authorSu, C.-M.zh_TW
dc.contributor.authorChen, Y.-H.zh_TW
dc.contributor.authorHuang, S.-Y.zh_TW
dc.contributor.authorWalzem, R. L.zh_TW
dc.contributor.authorChen, S.-E.zh_TW
dc.date2014-
dc.date.accessioned2015-08-04T07:59:37Z-
dc.date.available2015-08-04T07:59:37Z-
dc.identifier.issn0006-3363zh_TW
dc.identifier.issn1529-7268zh_TW
dc.identifier.issn1529-7268zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/86563-
dc.description.abstractLeukocytes are known to participate in ovarian activities in several species, but there is a surprising lack of information for the common chicken. Broiler hens consuming feed ad libitum (AL) exhibit a number of ovarian irregularities, but leukocyte functions are unstudied. In contrast to feed-restricted (R) hens, AL feeding for 7 wk significantly reduced egg production and clutch length while increasing pause length and atretic follicle numbers (P < 0.05). Granulosa cells from F1 follicles of AL hens contained less progesterone, and follicle walls were thicker with loose fibrous morphology and had less collagenase-3-like gelatinolytic activity but more IL-1beta (P < 0.05) production, suggestive of slower maturation in ovulatory process and inflamed necrosis. Interestingly, while highly infiltrated with immune cells, particularly heterophils, IL-1beta, MMP-22-like, and gelatinase A activities were reduced in AL hen peripheral heterophils and monocytes (P < 0.05); however, AL monocytes showed an increase in phagocytosis rate (P < 0.05). Generation of reactive oxygen intermediates was also suppressed in AL heterophils but increased in AL monocytes (P < 0.05). In contrast to leukocyte-free control, both AL and R heterophils and monocytes suppressed progesterone production and increased cell death in a dose-dependent manner when coincubated with granulosa cells at different ratios (P < 0.05). AL monocytes suppressed progesterone production more, but AL heterophils were less proapoptotic when compared to their R counterparts (P < 0.05). Alterations of cellular ceramide content (P < 0.05) corresponded to the discrepancy between heterophil and monocyte functionality. In conclusion, leukocyte dysfunction contributes to impaired ovarian activities of overfed broiler hens.zh_TW
dc.language.isoenzh_TW
dc.relationBiology of Reproduction, Volume 90, Issue 6, Page(s) 134-134.zh_TW
dc.subjectbroiler henszh_TW
dc.subjectceramidezh_TW
dc.subjectimmune cellszh_TW
dc.subjectmatrix metalloproteinaseszh_TW
dc.subjectobesityzh_TW
dc.subjectovaryzh_TW
dc.subjectAnimalszh_TW
dc.subjectApoptosiszh_TW
dc.subjectCaloric Restrictionzh_TW
dc.subjectCells, Culturedzh_TW
dc.subjectCeramideszh_TW
dc.subjectChickenszh_TW
dc.subjectCoculture Techniqueszh_TW
dc.subjectEatingzh_TW
dc.subjectFemalezh_TW
dc.subjectGranulosa Cellszh_TW
dc.subjectInterleukin-1betazh_TW
dc.subjectLeukocyteszh_TW
dc.subjectMatrix Metalloproteinase 13zh_TW
dc.subjectMatrix Metalloproteinase 2zh_TW
dc.subjectMonocyteszh_TW
dc.subjectObesityzh_TW
dc.subjectOvarian Folliclezh_TW
dc.subjectOvaryzh_TW
dc.subjectPhagocytosiszh_TW
dc.subjectProgesteronezh_TW
dc.subjectReproductionzh_TW
dc.subjectSphingomyelinszh_TW
dc.subjectAnimal Feedzh_TW
dc.titleFeed Intake Alters Immune Cell Functions and Ovarian Infiltration in Broiler Hens: Implications for Reproductive Performancezh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1095/biolreprod.113.115824zh_TW
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
Appears in Collections:動物科學系
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