Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/90114
標題: Interaction of Tetracyclines with non-ionic surfactant modified Bentonite.
四環素與非離子型界面活性劑改質膨潤土的交互作用
作者: Han-tien Wu
吳翰典
關鍵字: tetracyclin;non-ionic surfactant;bentonite;四環素;非離子型界面活性劑;膨潤土
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摘要: 
Tetracyclines (TCs) are commonly used as feed supplements to enhance animal growth or to treat diseases derived from microbial infections. Because TC cannot be completely metabolized in vivo, about 30-90 % TCs are excreted via the feces and urine as integral. As a result, TC has been found in many soils and natural waters, particularly in those areas near the farmlands. Inorganic colloids, such as clay minerals, distribute widely in the environments which may perform as a good adsorbent for TC or other pollutants because these minerals exhibit unique properties of small particle size and large surface area. Bentonite, one of the soil minerals consisting mainly of montmorillonite, can be a scavenger for environmental pollutants; however, the hydrophilic surfaces of bentonite may limit its application for removing less or non-polar organic molecules. Therefore, a cationic surfactant, such as alkyl amines, had been used to convert the bentonite surfaces becoming more hydrophobic to promote its adsorption capacity of non-polar molecules. Cationic surfactant exhibits a higher bio-toxicity, and this kind of surfactant may lead to a poison while being used as an antibiotic carrier. In this study, a non-ionic surfactant, i.e., Brij30, was used to modify bentonite, and its interaction with TC over a pH range of 3-8 was investigated. Results showed that TC adsorption on bentonite/or Brij30 modified bentonite could be described by the Langmuir model. However, Brij30 would inhibit TC adsorption on bentonite due probably to the blockage of the adsorptive sites of bentonite by Brij30. At pH 3, each bentonite sample exhibited a better adsorption ability of TC, attributing to the electrostatic attractions between TC and bentonite. The results of pH and ionic strengthen effects indicated that TC adsorption on Brij30-modified bentonite was more favorable at pH 8 than that at pH 5. This may be attributed to the hydrophobic interactions of TC molecules with Brij30. Besides, XRD diagram indicated that the d-spacing of TC-loading bentonite exhibited the highest at pH 8 which suggested that TC molecules may associate each other, probably through hydrophobic forces, prior to entering the interlayer of bentonite. FTIR spectra showed that the C=O from A ring and O=C-NH2 group may play an important role in TC adsorption.

四環黴素(TC),為一種常用的抗生素,長期以來一直被添加在動物飼料中用來治療病菌感染或是促進動物的生長,但大部分的抗生素不能在動物體內代謝掉,因此約有30-90%會經由動物的排泄物排出體外,可能導致其散佈在土壤及自然水體中。過去的研究指出,土壤中存在的無機膠體(如礦物)由於具粒徑小及比表面積大的優點,因此對抗生素等環境污染物具有一定的吸附能力,其中又以膨潤土(Bentonite)較常為學者所利用,此礦物為一種主要由蒙特石組成的黏土礦物,由於蒙特石親水性的表面卻不利於非極性分子的吸附,故常會加入陽離子界面活性劑,如烷胺類化合物使其成為有機膨潤土(organo-bentonite)來促進蒙特石類礦物對非極性分子的吸附能力。但陽離子型界面活性劑通常對生物的毒性較高,若作為抗生素的載體施用於動物飼料中將可能造成動物本身的毒害,因此,本研究以非離子型界面活性劑來改質黏土礦物膨潤土,瞭解此改質後的有機黏土與TC間的交互作用。結果顯示,改質前後之膨潤土對TC之吸附皆較符合Langmuir吸附模式,且膨潤土插層之非離子型界面活性劑在pH 5-8的條件下均無促進TC吸附的效果,反而會因佔據TC的吸附位置而抑制TC的吸附,因此對TC的吸附量皆有下降的現象。pH 3的條件下,因TC與帶負電的膨潤土表面會以靜電作用力吸引,故不論是否有經過Brij30改質,均有最高的TC吸附量;由pH及離子強度影響實驗發現,與pH 5的結果相較,在pH 8條件下有助於改質膨潤土對TC的吸附,XRD分析結果也顯示TC吸附後最大的層間距出現在pH 8,此可能是由於TC間疏水性作用的結合,使得進入層間的分子較大並與非離子型界面活性劑的疏水端作用,因而促進改質膨潤土對TC的吸附。而FTIR的分析結果則顯示,TC結構上A環、C環的C=O鍵與O=C-NH2鍵在膨潤土吸附上扮演著重要的角色。
URI: http://hdl.handle.net/11455/90114
Rights: 同意授權瀏覽/列印電子全文服務,2017-08-18起公開。
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