Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/90206
標題: 功能性便秘患者其體內腸胃道調節激素及維生素和營養狀態之評估與探討
Evaluation the content of gastrointestinal modulating hormones and vitamins & nutrient status on functional constipation patients
作者: 岳德政
Te-Cheng Yueh
關鍵字: Functional constipation;ghrelin;motilin;Nutritional status;Rome III diagnostic criteria;功能性便秘;胃動素;飢餓素;營養狀態;羅馬 III 診斷標準
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摘要: 
Backgrounds and purpose: Functional constipation, also known as chronic idiopathic constipation, has typical symptoms of constipation, but the exact causes remain
unknown. In addition, the prevalence of constipation in women is higher than in men. The clinical treatment and recommendation to improve the symptoms in constipation
patients include higher intake of fibers, supplementation with amounts of water, proper physical activity and stool softener administration. However, few studies have paid
attention to the nutritional status and gastrointestinal hormones in constipation patients. Herein, we focused on the middle-aged women with or without functional constipation to explore and compare the nutritional status and gastrointestinal hormones. Methods: We designed several questionnaires such as Rome III diagnostic criteria,
constipation severity instrument (CSI) scales, dietary habits, nutritional knowledge, subjective global assessment score, 24 h dietary recall, and clinical trial consent. We
then recruited the volunteers with functional constipation and healthy population from outpatient department and nursing staffs. The blood sample collected under fasting
condition was analyzed for biochemical parameters and gastrointestinal hormones. Results: Forty-eight volunteers were enrolled in this study (27 in the normal group and
21 in the constipation group. The CSI scales in the constipation group (34.2 ± 12.0) were significantly higher than those in the normal group (17.9 ± 9.1). In the functional constipation assessment, most parameters, except that of at least 25% of defecations by digital evacuation in the constipation group, were significantly higher in the normal group. In blood biochemical analysis, only the levels of potassium, zinc, and triiodothyronine were significantly higher in the normal group than in the constipation group. The levels of acylated ghrelin and motilin in the normal group were significant higher than those in the constipation. However, there were no statistical differences in dietary habits and nutritional knowledge between the normal and constipation group.
Conclusion: The present results provide some recommendations for clinical treatment and lifestyle modification for constipation patients. However, the sample size in this study is small, and a larger sample size study is needed to confirm these findings.

研究背景與目的:功能性便秘也稱為慢性原發性便秘,具有典型的便秘症狀,但造成的原因仍未知。此外便祕在女性的盛行率高於男性。在臨床上對於改善便秘症狀的治療與建議包括多攝取膳食纖維、補充水分、適當的運動以及服用軟便劑。然而,目前較少有研究針對便秘患者體內營養狀態及腸胃道荷爾蒙進行深入的探討。因此,本研究擬針對中年女性伴隨有功能性便秘的患者,探討並比較其體內營養狀態、飲食習慣及腸胃道荷爾蒙。研究方法:本研究導入許多相關問卷,如功能性便秘評估表(羅馬 III 診斷標準)、便秘嚴重度評估表、飲食習慣與營養知識問卷、主觀整體評估量表與 24 小時飲食回憶紀錄表以及人體試驗同意書。在門診期間招募符合功能性便祕的受試者及在本院護理同仁中招募同年齡族群女性。受試者空腹血液檢體進行一般生化與腸胃道荷爾蒙含量分析。研究結果:最終納入本研究之受試者共 48 位,正常組與便秘組分別為 27 與 21 位。其中便秘組(34.2 ± 12.0)的便秘嚴重程度分數顯著大於正常組(17.9 ± 9.1) 在功能性。便秘評估部分,大部分參數除了每四次排便中至少有一次需要以手指幫忙解便之外,便祕組均顯著高於正常組。在血液一般生化分析中,只有鉀離子、鋅離子與三碘甲狀腺素含量,兩組間有顯著差異。在腸胃道相關荷爾蒙含量如活化態飢餓素與胃動素,正常組顯著高於便祕組。然而在飲食習慣、營養知識與飲食內容上,兩組間則不具有顯著差異。結論:本研究提供了便秘患者在臨床上藥物治療與生活習慣調整的一些建議,但受限於受試者樣本數較少,可能需要進行更大規模的研究才能確定其相關性。
URI: http://hdl.handle.net/11455/90206
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