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標題: 以乳癌為例-全面性探討蛋白質轉譯後修飾作用之間的交互作用
Using Bioinformatics Methods to Identify PTMs Crosstalk: An Example of Breast Cancer
作者: Chian-Ying Chen
關鍵字: Post-Translational Modification;Interaction (Crosstalk);Breast Cancer;蛋白質轉譯後修飾;交互作用;乳癌
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Post-Translational Modifications (PTMs) of proteins have the significant associations with regulating cell physiological function, gene regulation, protein function, generation of major diseases. However, most of the current studies only explore for the single protein-translational modification, two or more post-translational modifications of proteins between the role relevant information on their interaction still very few.
As a result, in this study of breast cancer for example. According to the methods of bioinformatics, after collecting a large number of breast cancer associated proteins and verified post-translational modifications data, motif and domain related information. In this study, we obtain the post-translational sites between two or more interaction of post-translational modifications after the statistical tests and functional analysis of species conservation, and the analysis of sequence, motif and domain, and the results of the protein-protein, domain-domain interaction network related tools DOMINE, 3did and PTMcode.
In addition to investigate the correlation between the interactions of post-translational modifications, this study will supply the biological laboratories to do extended discussion with further regulatory pathway of biological and physiological functions related diseases.

其他識別: U0005-2811201416195151
Rights: 同意授權瀏覽/列印電子全文服務,2014-08-31起公開。
Appears in Collections:基因體暨生物資訊學研究所

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