Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/92612
標題: 研究糖尿病患者食用益生菌後血液細胞激素的表現
Study of serum cytokines expression in diabetes mellitus patients with eating probiotic
作者: 邱怡芳
Yi-Fang Chiu
關鍵字: 糖尿病;細胞激素;益生菌;diabetes mellitus;serum cytokines;probiotics
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摘要: 
根據國際糖尿病聯合會(IDF)最新公告,2013年全球20至70歲罹患糖尿病者高達3.82億人,預計2035年糖尿病人數將增至5.92億人,患病年齡層以40-59歲占最多,糖尿病是一個全球性的公共衛生問題,病程緩慢漸進且無明顯症狀,其併發症花費造成社會經濟負擔相當可觀。台灣的糖尿病以第2型糖尿病為主,約佔95%,近年來發現這類患者致病性與慢性發炎有關。目前已經有研究證實,食用益生菌可以減緩糖尿病病症,欲探討第2型糖尿病患者食用益生菌後血液細胞激素的表現,分析人體血液中細胞激素TNF-α、IL-1β、IL-6、IL-17、IL-10的濃度。結果TNF-α、IL-1β、IL-17在食用益生菌前與食用後濃度變化並無顯著差異,而IL-6在食用益生菌後低於食用前濃度,接近顯著差異(p=0.052),此外IL-10在食用益生菌後,濃度低於食用前,具有顯著差異(p=0.0006)。綜合以上研究結果,本實驗所採用之益生菌株對第2型糖尿病患者而言,食用益生菌後造成其體內部分細胞激素改變,可作為進一步研究之基礎與參考。

According to the latest announcement issued by International Diabetes Federation (IDF), people aging from 20 to 70 who suffer from diabetes reach 382 million in 2013 around the world, and it is estimated that this number will increase to 592 million in 2035. Most of the diabetes patients are at age of 40 to 59. Diabetes is a global public health problem. The disease progresses gradually and slowly without obvious symptoms. Its complications cost a lot, bringing a heavy burden to society and economy. Type 2 diabetes is dominant in the diabetes of Taiwan, approximately accounting for 95%. It is found in recent years that these patients' pathogenicity is associated with chronic inflammation. This study has confirmed that eating probiotics can reduce the symptoms of diabetes, and it is to explore the expression of serum cytokines for patients with type 2 diabetes after their eating probiotics, and to analyze the concentration of serum cytokines TNF-α, IL-1β, IL-6, IL-17 and IL-10 .
Results show that there is no significant difference for the concentration of TNF-α, IL-1β and IL-17 before and after eating probiotics, the concentration of IL-6 after eating probiotics is lower than that before eating probiotics, nearly reaching significant difference (p=0.052). Besides, the concentration of IL-10 after eating probiotics is lower than that before eating probiotics, having significant difference (p = 0.0006). The research results indicate that eating probiotics adopted in this experiment can change parts of cytokines in the body for diabetes patients with type 2 diabetes, which can be used as the basis and the reference of further study.
URI: http://hdl.handle.net/11455/92612
其他識別: U0005-1408201513284400
Rights: 不同意授權瀏覽/列印電子全文服務
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