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標題: 第二型糖尿病患者合併內頸動脈狹窄的心血管危險因子探討
Cardiovascular risk factors of internal carotid artery stenosis in type II diabetes
作者: 林曉菁
Hsiao-Ching Lin
關鍵字: 第二型糖尿病;內頸動脈狹窄;脂蛋白(a);高敏感性C-反應蛋白;type II diabetes mellitus;internal carotid artery stenosis;lipoprotein(a);high-sensitivity C-reactive protein
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本研究為橫斷性研究,共收集83位第二型糖尿病患者,其中有53位男性,30位女性,平均年齡為66.2 ± 6.3歲。所有患者均須接受顱外超音波檢測以確認是否有內頸動脈狹窄的情形。血液檢體測定包含血脂肪、凝血功能、纖維溶解功能及發炎參數等項目,並記錄心血管相關危險因子,包括高血壓、糖尿病、血脂異常、肥胖、抽菸、喝酒及運動情況。統計分析採用卡方檢定、獨立樣本t檢定及多元邏輯斯迴歸分析法。
內頸動脈狹窄的盛行率有28.9%(24例)。脂蛋白(a) (OR= 3.147,95% CI:1.134-8.739,P=0.028)及高敏感性C-反應蛋白(OR= 2.511,95% CI:1.022-6.168,P=0.045)為內頸動脈狹窄的獨立預測因子。

Carotid artery stenosis is an important cause of cerebral ischemia for patients with type II diabetes mellitus (DM). Carotid artery stenosis might induce ischemic stroke. It have been recognized as an useful tool to assess the risk of cerebrovascular diseases. Therefore, identifying the potential of developing cerebral infarction is clinically important for DM patients.
Present study investigated the cardiovascular related risk factors in type II DM.
This cross sectional study recruited 83 patients with type II DM. There were 53 men and 30 women. Their mean age was 66.2 ± 6.3 years. All patients underwent extracranial color-coded duplex sonography. We measured their lipid profile, coagulation, fibrinolytic and inflammation parameters. Cardiovascular risk factors including hypertension, diabetes mellitus, dyslipidemia, obesity, smoking, alcohol and physical activity were evaluated. Test statistics included the chi-spuare test, independent t test, and multiple logistic regression.
28.9% (n=24) of patients had internal carotid artery stenosis. Lipoprotein(a) (OR= 3.147, 95% CI:1.134-8.739, P=0.028) and high-sensitivity C-reactive protein (OR= 2.511, 95% CI:1.022-6.168, P=0.045) were the independent predictor for internal carotid artery stenosis.
Elevated Lp(a) and hs-CRP increased the risk of internal carotid artery stenosis in type II DM subjects.
其他識別: U0005-2301201401193500
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