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http://hdl.handle.net/11455/93040| 標題: | Correlation between molecular phenotypes,chemotherapy response and prognosis in canine malignant mammary tumors 犬惡性乳腺瘤之分子表型與化療反應及預後間的相關性 |
作者: | Li-Ren Wang 王俐人 |
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Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res 11, 925s-930s. | 摘要: | 乳腺瘤為母狗最常見的腫瘤之一，且約有半數病例為惡性。根據之前的研究，人類乳癌的分子表型或許可以做為犬惡性乳腺瘤的預後及化學療法反應評估。因此，本實驗目的在於利用人類乳癌的分子表型為犬惡性乳腺瘤分型，並分析分子表型於患犬與預後及化療反應的關係。病例來自於 49 隻患有惡性乳腺癌的患犬，利用免疫組織化學染色技術分析動情素受器(estrogen receptor, ER)、黃體助孕素受器(progesterone receptor, PR)、人類上皮生長因子受器-2(human epidermal growthfactor receptor 2, HER-2)及 Ki-67 的表現。所有樣本依照三種不同分類方式被分為五型、四型、或是三型分子表型。結果顯示無論在哪一種分類方式，在沒有接受化療的患犬中，為基底樣型(basal-like type)惡性乳腺瘤的患犬有較高臨床分期、腫瘤組織學惡性程度分級較高、較容易發生遠端轉移、以及擁有較低的存活率；此外，比較分子表型與存活率與化療反應的關係，患犬接受化療的存活率以有表現HER-2 的組別如五型中的 luminal B HER-2 positive 及 HER-2 overexpression，四型中的 luminal B 及 HER-2 overexpression，三型中的 HER-2 overexpression 較高。而即使接受化療，於 basal-like type 的患犬多數於一年內死亡。因此，我們推論犬隻惡性乳腺瘤的分子表現型，應可作為評估預後與化療反應的因子。 Canine mammary tumors (CMTs) are the most common neoplasm in female dogs and approximate half of them are malignant. Molecular phenotypes of human breast cancers (HBCs) might be used to correlate prognosis and chemotherapy response in dogs with malignant mammary tumors. Therefore, the aims of this study were to categorize malignant CMTs via molecular phenotype classification of HBCs and analyze the correlations between phenotypes, prognosis and chemotherapy response. Neoplastic specimens were obtained from 49 dogs with malignant CMTs and the expressions of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 were detected by immunohistochemical staining. All samples were classified into three different kinds of classification including five types, four types, and three types of molecular phenotype. Results showed that regardless any kinds of classification, dogs without receiving chemotherapy in basal-like type were more likely to have advanced stage, high grade, distant metastasis, and shorter survival times. Besides, comparing overall survival rates with chemotherapy response in dogs with three different kinds of molecular phenotype classification in malignant CMTs, the survival rates were tended to be higher with overexpressing HER-2, that is, luminal B HER-2 positive and HER-2 overexpression types in 5 type, luminal B and HER-2 overexpression type in four type, and HER-2 overexpression type in three type of molecular phenotype. However, dogs with basal-like type tumor mostly died in one year follow-up even though they receiving chemotherapy. Therefore, it is suggested that molecular phenotypes in malignant CMTs may be suitable prognostic factors to survival and chemotherapy response. |
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