Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/93060
DC FieldValueLanguage
dc.contributor何素鵬zh_TW
dc.contributorShu-Peng Hoen_US
dc.contributor.authorYen-Chun Pengen_US
dc.contributor.author彭彥鈞zh_TW
dc.contributor.other獸醫學系暨研究所zh_TW
dc.date2015zh_TW
dc.date.accessioned2015-12-16T06:24:37Z-
dc.identifierU0005-0302201500101000zh_TW
dc.identifier.citationAbdel-Latif, M. M., H. Windle, A. Terres, D. N. Eidhin, D. Kelleher and J. V. Reynolds (2006). 'Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells.' J Gastrointest Surg 10(4): 551-562. Abraham, N. S. (2012). 'Proton pump inhibitors: potential adverse effects.' Curr Opin Gastroenterol 28(6): 615-620. Aghai, Z. H., A. Kode, J. G. Saslow, T. Nakhla, S. Farhath, G. E. Stahl, R. Eydelman, L. Strande, P. Leone and I. Rahman (2007). 'Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants.' Pediatr Res 62(4): 483-488. Ahmed, N., T. Wiedemann, E. Loell, S. Mueller, M. Stoeckelhuber, M. Stolte, R. Haas and G. Rieder (2009). 'Helicobacter pylori cag-Pathogenicity Island-Dependent Early Immunological Response Triggers Later Precancerous Gastric Changes in Mongolian Gerbils.' PLoS ONE 4(3): e4754. Auerbach, T., A. Bashan and A. Yonath (2004). 'Ribosomal antibiotics: structural basis for resistance, synergism and selectivity.' Trends Biotechnol 22(11): 570-576. Backert, S., T. Schwarz, S. Miehlke, C. Kirsch, C. Sommer, T. Kwok, M. Gerhard, U. B. Goebel, N. Lehn, W. Koenig and T. F. Meyer (2004). 'Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer.' Infect Immun 72(2): 1043-1056. Baggiolini, M., B. Dewald and B. Moser (1997). 'Human chemokines: an update.' Annu Rev Immunol 15: 675-705. Baiocchi, G. L., N. Vettoretto, D. Colombrita, M. Giovanetti, A. Coniglio, S. Bonardelli, A. Pelizzari, M. Ronconi, G. A. Tiberio and S. M. Giulini (2002). 'Is there an association between Helicobacter pylori cytotoxin Cag A seropositivity and risk for gastric cancer?' Ann Ital Chir 73(6): 571-576; discussion 577-578. Balkwill, F. and A. Mantovani (2001). 'Inflammation and cancer: back to Virchow?' Lancet 357(9255): 539-545. Barcellos-Hoff, M. H., D. Lyden and T. C. Wang (2013). 'The evolution of the cancer niche during multistage carcinogenesis.' Nat Rev Cancer 13(7): 511-518. Barlow, D. P. and M. S. Bartolomei (2014). 'Genomic imprinting in mammals.' Cold Spring Harb Perspect Biol 6(2). Bartchewsky, W., Jr., M. R. Martini, M. Masiero, A. C. Squassoni, M. C. Alvarez, M. S. Ladeira, D. Salvatore, M. Trevisan, J. Pedrazzoli, Jr. and M. L. Ribeiro (2009). 'Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer.' Scand J Gastroenterol 44(2): 153-161. Basso, D., M. Scrigner, A. Toma, F. Navaglia, F. Di Mario, M. Rugge and M. Plebani (1996). 'Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2.' Int J Clin Lab Res 26(3): 207-210. Bateman, D. N., D. Colin-Jones, S. Hartz, M. Langman, R. F. Logan, J. Mant, M. Murphy, K. R. Paterson, R. Rowsell, S. Thomas, M. Vessey and S. Group (2003). 'Mortality study of 18 000 patients treated with omeprazole.' Gut 52(7): 942-946. Blaser, M. J. (2004). 'Helicobacter pylori persistence: biology and disease.' Journal of Clinical Investigation 113(3): 321-333. Bonizzi, G. and M. Karin (2004). 'The two NF-κB activation pathways and their role in innate and adaptive immunity.' Trends in Immunology 25(6): 280-288. Brandt, S. (2005). 'NF- B activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein.' Proceedings of the National Academy of Sciences 102(26): 9300-9305. Censini, S., C. Lange, Z. Xiang, J. E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli and A. Covacci (1996). 'cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.' Proc Natl Acad Sci U S A 93(25): 14648-14653. Chen, L.-F. and W. C. Greene (2004). 'Shaping the nuclear action of NF-κB.' Nature Reviews Molecular Cell Biology 5(5): 392-401. Chen, X. X., S. Q. Shang, Q. H. Lai, B. Ou, L. Chen, X. Wu and X. Zhang (2003). '[Association between gastroduodenal diseases and cagA, vacA gene expressions of Helicobacter pylori].' Zhonghua Er Ke Za Zhi 41(1): 56-57. Cid, T. P., M. C. Fernandez, S. Benito Martinez and N. L. Jones (2013). 'Pathogenesis of Helicobacter pylori infection.' Helicobacter 18 Suppl 1: 12-17. Cote, G. A. and C. W. Howden (2008). 'Potential adverse effects of proton pump inhibitors.' Curr Gastroenterol Rep 10(3): 208-214. Crabtree, J. E., A. Covacci, S. M. Farmery, Z. Xiang, D. S. Tompkins, S. Perry, I. J. Lindley and R. Rappuoli (1995). 'Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.' J Clin Pathol 48(1): 41-45. Crabtree, J. E., T. M. Shallcross, R. V. Heatley and J. I. Wyatt (1991). 'Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.' Gut 32(12): 1473-1477. Daxinger, L. and E. Whitelaw (2012). 'Understanding transgenerational epigenetic inheritance via the gametes in mammals.' Nat Rev Genet 13(3): 153-162. de Martel, C., J. Ferlay, S. Franceschi, J. Vignat, F. Bray, D. Forman and M. Plummer (2012). 'Global burden of cancers attributable to infections in 2008: a review and synthetic analysis.' Lancet Oncol 13(6): 607-615. Deguchi, R., M. Igarashi, K. Watanabe and A. Takagi (2004). 'Analysis of the cag pathogenicity island and IS605 of Helicobacter pylori strains isolated from patients with gastric cancer in Japan.' Aliment Pharmacol Ther 20 Suppl 1: 13-16. Deshpande, A., V. Pasupuleti, P. Thota, C. Pant, S. Mapara, S. Hassan, D. D. Rolston, T. J. Sferra and A. V. Hernandez (2013). 'Acid-suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis.' J Gastroenterol Hepatol 28(2): 235-242. Dixon, M. F., R. M. Genta, J. H. Yardley and P. Correa (1996). 'Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994.' Am J Surg Pathol 20(10): 1161-1181. el-Zimaity, H. M., F. W. Jackson and D. Y. Graham (1997). 'Fundic gland polyps developing during omeprazole therapy.' Am J Gastroenterol 92(10): 1858-1860. Farinati, F., R. Cardin, V. M. Russo, G. Busatto, M. Franco and M. Rugge (2003). 'Helicobacter pylori CagA status, mucosal oxidative damage and gastritis phenotype: a potential pathway to cancer?' Helicobacter 8(3): 227-234. Fischbach, W. (2014). 'Gastric MALT lymphoma - Update on diagnosis and treatment.' Best Pract Res Clin Gastroenterol 28(6): 1069-1077. Fischer, H., V. Huber, P. Boknik, H. Luess, J. Neumann, W. Schmitz, W. Domschke and J. W. Konturek (2001). 'Effect of Helicobacter pylori eradication on cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression during gastric adaptation to aspirin (ASA) in humans.' Microsc Res Tech 53(5): 336-342. Ford, A. C., D. Forman, R. H. Hunt, Y. Yuan and P. Moayyedi (2014). 'Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials.' BMJ 348: g3174. Fox, J. G. and E. J. Kuipers (2011). 'Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil.' Gut 60(5): 567-568. Franceschi, F., G. Zuccala, D. Roccarina and A. Gasbarrini (2014). 'Clinical effects of Helicobacter pylori outside the stomach.' Nat Rev Gastroenterol Hepatol 11(4): 234-242. Fuccio, L., R. M. Zagari, M. E. Minardi and F. Bazzoli (2007). 'Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer.' Aliment Pharmacol Ther 25(2): 133-141. Fujimura, T., T. Ohta, K. Oyama, T. Miyashita and K. Miwa (2007). 'Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers.' J Gastrointest Cancer 38(2-4): 78-82. Genta, R. M., G. Rindi, R. Fiocca, D. J. Magner, D. D'Amico and D. S. Levine (2003). 'Effects of 6-12 months of esomeprazole treatment on the gastric mucosa.' Am J Gastroenterol 98(6): 1257-1265. Gionchetti, P., D. Vaira, M. Campieri, J. Holton, M. Menegatti, A. Belluzzi, E. Bertinelli, M. Ferretti, C. Brignola, M. Miglioli and et al. (1994). 'Enhanced mucosal interleukin-6 and -8 in Helicobacter pylori-positive dyspeptic patients.' Am J Gastroenterol 89(6): 883-887. Godaly, G., A. E. Proudfoot, R. E. Offord, C. Svanborg and W. W. Agace (1997). 'Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration.' Infect Immun 65(8): 3451-3456. Griffin, S. M. and S. A. Raimes (1998). 'Proton pump inhibitors may mask early gastric cancer. Dyspeptic patients over 45 should undergo endoscopy before these drugs are started.' Bmj 317(7173): 1606-1607. Grivennikov, S. I. and M. Karin (2011). 'Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage.' Annals of the Rheumatic Diseases 70(Suppl 1): i104-i108. Hagiwara, T., K. Mukaisho, T. Nakayama, H. Sugihara and T. Hattori (2011). 'Long-term proton pump inhibitor administration worsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infected with Helicobacter pylori.' Gut 60(5): 624-630. Hanahan, D. and R. A. Weinberg (2000). 'The hallmarks of cancer.' Cell 100(1): 57-70. Handa, O., N. Yoshida, N. Fujita, Y. Tanaka, M. Ueda, T. Takagi, S. Kokura, Y. Naito, T. Okanoue and T. Yoshikawa (2006). 'Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors.' Inflamm Res 55(11): 476-480. Haruna, H., T. Shimizu, Y. Ohtsuka, Y. Yarita, T. Fujii, T. Kudo and Y. Yamashiro (2008). 'Expression of COX-1, COX-2, and PPAR-gamma in the gastric mucosa of children with Helicobacter pylori infection.' Pediatr Int 50(1): 1-6. Hatakeyama, M. (2004). 'Oncogenic mechanisms of the Helicobacter pylori CagA protein.' Nature Reviews Cancer 4(9): 688-694. Havu, N. (1986). 'Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion.' Digestion 35 Suppl 1: 42-55. Hayden, M. S. (2004). 'Signaling to NF- B.' Genes & Development 18(18): 2195-2224. Herrero, R., J. Y. Park and D. Forman (2014). 'The fight against gastric cancer - the IARC Working Group report.' Best Pract Res Clin Gastroenterol 28(6): 1107-1114. Hohenberger, P. and S. Gretschel (2003). 'Gastric cancer.' Lancet 362(9380): 305-315. Hou, W. and M. L. Schubert (2006). 'Gastric secretion.' Curr Opin Gastroenterol 22(6): 593-598. Hsu, P. I., I. R. Hwang, D. Cittelly, K. H. Lai, H. M. El-Zimaity, O. Gutierrez, J. G. Kim, M. S. Osato, D. Y. Graham and Y. Yamaoka (2002). 'Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island.' Am J Gastroenterol 97(9): 2231-2238. Hsu, W. Y., C. H. Lin, C. C. Lin, F. C. Sung, C. P. Hsu and C. H. Kao (2014). 'The relationship between Helicobacter pylori and cancer risk.' Eur J Intern Med 25(3): 235-240. Huang, F. Y., A. O. Chan, A. Rashid, D. K. Wong, C. H. Cho and M. F. Yuen (2012). 'Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1beta activation of nitric oxide production in gastric cancer cells.' Cancer 118(20): 4969-4980. Huang, J., P. W. O'Toole, P. Doig and T. J. Trust (1995). 'Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori.' Infect Immun 63(5): 1732-1738. Huang, J. Q., G. F. Zheng, K. Sumanac, E. J. Irvine and R. H. Hunt (2003). 'Meta-analysis of the relationship between cagA seropositivity and gastric cancer.' Gastroenterology 125(6): 1636-1644. Ichiyama, T., M. Nishikawa, T. Yoshitomi, S. Hasegawa, T. Matsubara, T. Hayashi and S. Furukawa (2001). 'Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells.' Antimicrob Agents Chemother 45(1): 44-47. Ishikawa, M., F. Okada, J. Hamada, M. Hosokawa and H. Kobayashi (1987). 'Changes in the tumorigenic and metastatic properties of tumor cells treated with quercetin or 5-azacytidine.' Int J Cancer 39(3): 338-342. Jawa, R. S., S. Anillo, K. Huntoon, H. Baumann and M. Kulaylat (2011). 'Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science.' J Intensive Care Med 26(1): 3-12. Jawa, R. S., S. Anillo, K. Huntoon, H. Baumann and M. Kulaylat (2011). 'Interleukin-6 in surgery, trauma, and critical care part II: clinical implications.' J Intensive Care Med 26(2): 73-87. Johannessen, M., F. Askarian, M. Sangvik and J. E. Sollid (2013). 'Bacterial interference with canonical NFκB signalling.' Microbiology 159(Pt 10): 2001-2013. Keates, S., A. C. Keates, M. Warny, R. M. Peek, Jr., P. G. Murray and C. P. Kelly (1999). 'Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori.' J Immunol 163(10): 5552-5559. Kikuchi, T. (2002). 'Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappaB transcription factors.' Journal of Antimicrobial Chemotherapy 49(5): 745-755. Kim, H., J. W. Lim and K. H. Kim (2001). 'Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaB.' Scand J Gastroenterol 36(7): 706-716. Kim, J. S., J. M. Kim, H. C. Jung and I. S. Song (2001). 'Expression of cyclooxygenase-2 in human neutrophils activated by Helicobacter pylori water-soluble proteins: possible involvement of NF-kappaB and MAP kinase signaling pathway.' Dig Dis Sci 46(10): 2277-2284. Kim, S. S., Y. J. Sung, M. K. Park, C. H. Lim, H. J. Yang, T. H. Kim, C. W. Kim, J. I. Kim, S. W. Han and I. S. Chung (2008). '[The change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of Helicobacter pylori].' Korean J Gastroenterol 52(5): 286-292. Kountouras, J., C. Zavos and D. Chatzopoulos (2004). 'Induction of interleukin-8 expression by Helicobacter pylori infection in patients with endoscopy-negative gastroesophageal reflux disease.' Am J Gastroenterol 99(12): 2500-2501; author reply 2501-2502. Kuipers, E. J. (2006). 'Proton pump inhibitors and gastric neoplasia.' Gut 55(9): 1217-1221. Kuipers, E. J., E. C. Klinkenberg-Knol and S. G. Meuwissen (2000). 'Omeprazole and accelerated onset of atrophic gastritis.' Gastroenterology 118(1): 239-242. Kuipers, E. J., L. Lundell, E. C. Klinkenberg-Knol, N. Havu, H. P. Festen, B. Liedman, C. B. Lamers, J. B. Jansen, J. Dalenback, P. Snel, G. F. Nelis and S. G. Meuwissen (1996). 'Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication.' N Engl J Med 334(16): 1018-1022. Kuipers, E. J., G. I. Perez-Perez, S. G. Meuwissen and M. J. Blaser (1995). 'Helicobacter pylori and atrophic gastritis: importance of the cagA status.' J Natl Cancer Inst 87(23): 1777-1780. Kunst, F., N. Ogasawara, I. Moszer, A. M. Albertini, G. Alloni, V. Azevedo, M. G. Bertero, P. Bessieres, A. Bolotin, S. Borchert, R. Borriss, L. Boursier, A. Brans, M. Braun, S. C. Brignell, S. Bron, S. Brouillet, C. V. Bruschi, B. Caldwell, V. Capuano, N. M. Carter, S. K. Choi, J. J. Cordani, I. F. Connerton, N. J. Cummings, R. A. Daniel, F. Denziot, K. M. Devine, A. Dusterhoft, S. D. Ehrlich, P. T. Emmerson, K. D. Entian, J. Errington, C. Fabret, E. Ferrari, D. Foulger, C. Fritz, M. Fujita, Y. Fujita, S. Fuma, A. Galizzi, N. Galleron, S. Y. Ghim, P. Glaser, A. Goffeau, E. J. Golightly, G. Grandi, G. Guiseppi, B. J. Guy, K. Haga, J. Haiech, C. R. Harwood, A. Henaut, H. Hilbert, S. Holsappel, S. Hosono, M. F. Hullo, M. Itaya, L. Jones, B. Joris, D. Karamata, Y. Kasahara, M. Klaerr-Blanchard, C. Klein, Y. Kobayashi, P. Koetter, G. Koningstein, S. Krogh, M. Kumano, K. Kurita, A. Lapidus, S. Lardinois, J. Lauber, V. Lazarevic, S. M. Lee, A. Levine, H. Liu, S. Masuda, C. Mauel, C. Medigue, N. Medina, R. P. Mellado, M. Mizuno, D. Moestl, S. Nakai, M. Noback, D. Noone, M. O'Reilly, K. Ogawa, A. Ogiwara, B. Oudega, S. H. Park, V. Parro, T. M. Pohl, D. Portelle, S. Porwollik, A. M. Prescott, E. Presecan, P. Pujic, B. Purnelle, G. Rapoport, M. Rey, S. Reynolds, M. Rieger, C. Rivolta, E. Rocha, B. Roche, M. Rose, Y. Sadaie, T. Sato, E. Scanlan, S. Schleich, R. Schroeter, F. Scoffone, J. Sekiguchi, A. Sekowska, S. J. Seror, P. Serror, B. S. Shin, B. Soldo, A. Sorokin, E. Tacconi, T. Takagi, H. Takahashi, K. Takemaru, M. Takeuchi, A. Tamakoshi, T. Tanaka, P. Terpstra, A. Togoni, V. Tosato, S. Uchiyama, M. Vandebol, F. Vannier, A. Vassarotti, A. Viari, R. Wambutt, H. Wedler, T. Weitzenegger, P. Winters, A. Wipat, H. Yamamoto, K. Yamane, K. Yasumoto, K. Yata, K. Yoshida, H. F. Yoshikawa, E. Zumstein, H. Yoshikawa and A. Danchin (1997). 'The complete genome sequence of the gram-positive bacterium Bacillus subtilis.' Nature 390(6657): 249-256. Kuwana, M. (2014). 'Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms.' World J Gastroenterol 20(3): 714-723. Lai, C. H., C. L. Perng, K. H. Lan and H. J. Lin (2013). 'Association of IS605 and cag-PAI of Helicobacter pylori Isolated from Patients with Gastrointestinal Diseases in Taiwan.' Gastroenterol Res Pract 2013: 356217. Lamb, A. and L. F. Chen (2010). 'The many roads traveled by Helicobacter pylori to NFkappaB activation.' Gut Microbes 1(2): 109-113. Lamb, A., X. D. Yang, Y. H. Tsang, J. D. Li, H. Higashi, M. Hatakeyama, R. M. Peek, S. R. Blanke and L. F. Chen (2009). 'Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.' EMBO Rep 10(11): 1242-1249. Lau, J. Y., A. Barkun, D. M. Fan, E. J. Kuipers, Y. S. Yang and F. K. Chan (2013). 'Challenges in the management of acute peptic ulcer bleeding.' Lancet 381(9882): 2033-2043. Lee, K. E., P. N. Khoi, Y. Xia, J. S. Park, Y. E. Joo, K. K. Kim, S. Y. Choi and Y. D. Jung (2013). 'Helicobacter pylori and interleukin-8 in gastric cancer.' World J Gastroenterol 19(45): 8192-8202. Lin, J. T., J. T. Wang, T. H. Wang, M. S. Wu and C. J. Chen (1993). 'Helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 Taiwanese patients.' Hepatogastroenterology 40(6): 596-599. Lin, J. T., J. T. Wang, T. H. Wang, M. S. Wu, T. K. Lee and C. J. Chen (1993). 'Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. A seroprevalence study in Taiwan.' Scand J Gastroenterol 28(12): 1067-1072. Lind, T., F. Megraud, P. Unge, E. Bayerdorffer, C. O'Morain, R. Spiller, S. Veldhuyzen Van Zanten, K. D. Bardhan, M. Hellblom, M. Wrangstadh, L. Zeijlon and C. Cederberg (1999). 'The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies.' Gastroenterology 116(2): 248-253. Lindholm, C., M. Quiding-Jarbrink, H. Lonroth and A. M. Svennerholm (2001). 'Induction of chemokine and cytokine responses by Helicobacter pylori in human stomach explants.' Scand J Gastroenterol 36(10): 1022-1029. Loh, J. T., D. B. Friedman, M. B. Piazuelo, L. E. Bravo, K. T. Wilson, R. M. Peek, Jr., P. Correa and T. L. Cover (2012). 'Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression.' Infect Immun 80(9): 3094-3106. Lukaszewicz-Zajac, M., B. Mroczko and M. Szmitkowski (2010). '[The role of interleukin-6 and C-reactive protein in gastric cancer].' Pol Merkur Lekarski 29(174): 382-386. Lundell, L., P. Miettinen, H. E. Myrvold, S. A. Pedersen, K. Thor, A. Andersson, J. Hattlebakk, N. Havu, E. Janatuinen, K. Levander, B. Liedman and P. Nystrom (1999). 'Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group.' Gastroenterology 117(2): 319-326. Luster, A. D. (1998). 'Chemokines--chemotactic cytokines that mediate inflammation.' N Engl J Med 338(7): 436-445. Malfertheiner, P., F. K. Chan and K. E. McColl (2009). 'Peptic ulcer disease.' Lancet 374(9699): 1449-1461. Malfertheiner, P., F. Megraud, C. O'Morain, F. Bazzoli, E. El-Omar, D. Graham, R. Hunt, T. Rokkas, N. Vakil and E. J. Kuipers (2007). 'Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.' Gut 56(6): 772-781. Malfertheiner, P., F. Megraud, C. A. O'Morain, J. Atherton, A. T. Axon, F. Bazzoli, G. F. Gensini, J. P. Gisbert, D. Y. Graham, T. Rokkas, E. M. El-Omar, E. J. Kuipers and G. European Helicobacter Study (2012). 'Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report.' Gut 61(5): 646-664. Marshall, B. J. and J. R. Warren (1984). 'Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.' Lancet 1(8390): 1311-1315. Maton, P. N. (1991). 'Omeprazole.' N Engl J Med 324(14): 965-975. McColl, K. E. (2010). 'Clinical practice. Helicobacter pylori infection.' N Engl J Med 362(17): 1597-1604. McLean, M. H. and E. M. El-Omar (2014). 'Genetics of gastric cancer.' Nat Rev Gastroenterol Hepatol 11(11): 664-674. Mircic, M. and A. Kavanaugh (2011). 'Inhibition of IL6 in rheumatoid arthritis and juvenile idiopathic arthritis.' Experimental Cell Research 317(9): 1286-1292. Misiewicz, J. J. (1991). 'The Sydney System: a new classification of gastritis. Introduction.' J Gastroenterol Hepatol 6(3): 207-208. Miwa, H., M. F. Go and N. Sato (2002). 'H. pylori and gastric cancer: the Asian enigma.' Am J Gastroenterol 97(5): 1106-1112. Miyashita, T., F. A. Shah, K. Miwa, S. Sasaki, K. Nishijima, K. Oyama, I. Ninomiya, S. Fushida, T. Fujimura, T. Hattori, J. W. Harmon and T. Ohta (2013). 'Impact of inflammation-metaplasia-adenocarcinoma sequence and prevention in surgical rat models.' Digestion 87(1): 6-11. Moayyedi, P., C. Wason, R. Peacock, A. Walan, K. Bardhan, A. T. Axon and M. F. Dixon (2000). 'Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression.' Helicobacter 5(4): 206-214. Morson, B. C. (1955). 'Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa.' Br J Cancer 9(3): 377-385. Morson, B. C. (1955). 'Intestinal metaplasia of the gastric mucosa.' Br J Cancer 9(3): 365-376. Mukaida, N. (2000). 'Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation.' Int J Hematol 72(4): 391-398. Mustapha, P., I. Paris, M. Garcia, C. T. Tran, J. Cremniter, M. Garnier, J. P. Faure, T. Barthes, I. G. Boneca, F. Morel, J. C. Lecron, C. Burucoa and C. Bodet (2014). 'Chemokines and antimicrobial peptides have a cag-dependent early response to Helicobacter pylori infection in primary human gastric epithelial cells.' Infect Immun 82(7): 2881-2889. Nozawa, Y., K. Nishihara, R. M. Peek, M. Nakano, T. Uji, H. Ajioka, N. Matsuura and H. Miyake (2002). 'Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells.' Biochem Pharmacol 64(1): 21-30. O'Connor, A., J. Molina-Infante, J. P. Gisbert and C. O'Morain (2013). 'Treatment of Helicobacter pylori infection 2013.' Helicobacter 18 Suppl 1: 58-65. Odenbreit, S. (2000). 'Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion.' Science 287(5457): 1497-1500. Odenbreit, S., S. Linder, B. Gebert-Vogl, G. Rieder, A. P. Moran and R. Haas (2006). 'Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis.' Helicobacter 11(3): 196-207. Ogawa, M., J. Suzuki, K. Takayama and M. Isobe (2009). 'Matrix metalloproteinase suppression induced by clarithromycin in murine cardiac allografts.' Transplant Proc 41(1): 395-397. Ohkuma, K., M. Okada, H. Murayama, M. Seo, K. Maeda, M. Kanda and N. Okabe (2000). 'Association of Helicobacter pylori infection with atrophic gastritis and intestinal metaplasia.' J Gastroenterol Hepatol 15(10): 1105-1112. Ohnishi, N., H. Yuasa, S. Tanaka, H. Sawa, M. Miura, A. Matsui, H. Higashi, M. Musashi, K. Iwabuchi, M. Suzuki, G. Yamada, T. Azuma and M. Hatakeyama (2008). 'Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.' Proc Natl Acad Sci U S A 105(3): 1003-1008. Okada, F. (2014). 'Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms.' Yonago Acta Med 57(2): 65-72. Okada, F., M. Hosokawa, J. Hasegawa, M. Ishikawa, I. Chiba, Y. Nakamura and H. Kobayashi (1990). 'Regression mechanisms of mouse fibrosarcoma cells after in vitro exposure to quercetin: diminution of tumorigenicity with a corresponding decrease in the production of prostaglandin E2.' Cancer Immunol Immunother 31(6): 358-364. Olbe, L., E. Carlsson and P. Lindberg (2003). 'A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole.' Nat Rev Drug Discov 2(2): 132-139. Peek, R. M., Jr. and M. J. Blaser (2002). 'Helicobacter pylori and gastrointestinal tract adenocarcinomas.' Nat Rev Cancer 2(1): 28-37. Peleteiro, B., A. Bastos, A. Ferro and N. Lunet (2014). 'Prevalence of Helicobacter pylori infection worldwide: a systematic review of studies with national coverage.' Dig Dis Sci 59(8): 1698-1709. Pereira, M. I. and J. A. Medeiros (2014). 'Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas.' World J Gastroenterol 20(3): 684-698. Peterson, W. L. (1991). 'Helicobacter pylori and peptic ulcer disease.' N Engl J Med 324(15): 1043-1048. Plummer, M., S. Franceschi, J. Vignat, D. Forman and C. de Martel (2015). 'Global burden of gastric cancer attributable to Helicobacter pylori.' Int J Cancer 136(2): 487-490. Poulsen, A. H., S. Christensen, J. K. McLaughlin, R. W. Thomsen, H. T. Sorensen, J. H. Olsen and S. Friis (2009). 'Proton pump inhibitors and risk of gastric cancer: a population-based cohort study.' Br J Cancer 100(9): 1503-1507. Quante, M., J. Varga, T. C. Wang and F. R. Greten (2013). 'The gastrointestinal tumor microenvironment.' Gastroenterology 145(1): 63-78. Rieder, G., J. L. Merchant and R. Haas (2005). 'Helicobacter pylori cag-Type IV Secretion System Facilitates Corpus Colonization to Induce Precancerous Conditions in Mongolian Gerbils.' Gastroenterology 128(5): 1229-1242. Rinaldi, M., C. Perricone, O. D. Ortega-Hernandez, R. Perricone and Y. Shoenfeld (2014). 'Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines.' Lupus 23(6): 554-567. Ritter, B., P. Kilian, M. R. Reboll, K. Resch, J. K. DiStefano, R. Frank, W. Beil and M. Nourbakhsh (2011). 'Differential effects of multiplicity of infection on Helicobacter pylori-induced signaling pathways and interleukin-8 gene transcription.' J Clin Immunol 31(1): 60-68. Rizzo, M. T. (2011). 'Cyclooxygenase-2 in oncogenesis.' Clin Chim Acta 412(9-10): 671-687. Robertson, D. J., H. Larsson, S. Friis, L. Pedersen, J. A. Baron and H. T. Sorensen (2007). 'Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study.' Gastroenterology 133(3): 755-760. Sadarangani, S. P., L. L. Estes and J. M. Steckelberg (2015). 'Non-anti-infective Effects of Antimicrobials and Their Clinical Applications: A Review.' Mayo Clin Proc 90(1): 109-127. Saltzman, J. R., J. A. Kemp, B. B. Golner, M. C. Pedrosa, G. E. Dallal and R. M. Russell (1994). 'Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption.' J Am Coll Nutr 13(6): 584-591. Scheidereit, C. (2006). 'IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.' Oncogene 25(51): 6685-6705. Scheller, J., A. Chalaris, D. Schmidt-Arras and S. Rose-John (2011). 'The pro- and anti-inflammatory properties of the cytokine interleukin-6.' Biochim Biophys Acta 1813(5): 878-888. Schenk, B. E., E. J. Kuipers, E. C. Klinkenberg-Knol, E. C. Bloemena, M. Sandell, G. F. Nelis, P. Snel, H. P. Festen and S. G. Meuwissen (1999). 'Atrophic gastritis during long-term omeprazole therapy affects serum vitamin B12 levels.' Aliment Pharmacol Ther 13(10): 1343-1346. Schenk, B. E., E. J. Kuipers, G. F. Nelis, E. Bloemena, J. C. Thijs, P. Snel, A. E. Luckers, E. C. Klinkenberg-Knol, H. P. Festen, P. P. Viergever, J. Lindeman and S. G. Meuwissen (2000). 'Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy.' Gut 46(5): 615-621. Schubert, M. L. and D. A. Peura (2008). 'Control of gastric acid secretion in health and disease.' Gastroenterology 134(7): 1842-1860. Schweitzer, K., O. Sokolova, P. M. Bozko and M. Naumann (2010). 'Helicobacter pylori induces NF-kappaB independent of CagA.' EMBO Rep 11(1): 10-11; author reply 11-12. Segal, E. D., J. Cha, J. Lo, S. Falkow and L. S. Tompkins (1999). 'Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori.' Proc Natl Acad Sci U S A 96(25): 14559-14564. Sharma, S. A., M. K. Tummuru, M. J. Blaser and L. D. Kerr (1998). 'Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells.' J Immunol 160(5): 2401-2407. Sheen, E. and G. Triadafilopoulos (2011). 'Adverse effects of long-term proton pump inhibitor therapy.' Dig Dis Sci 56(4): 931-950. Shimada, T. and A. Terano (1998). 'Chemokine expression in Helicobacter pylori-infected gastric mucosa.' J Gastroenterol 33(5): 613-617. Shimoyama, T., S. M. Everett, M. F. Dixon, A. T. Axon and J. E. Crabtree (1998). 'Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis.' J Clin Pathol 51(10): 765-770. Shiota, S., R. Suzuki and Y. Yamaoka (2013). 'The significance of virulence factors in Helicobacter pylori.' J Dig Dis 14(7): 341-349. Shiotani, A., P. Cen and D. Y. Graham (2013). 'Eradication of gastric cancer is now both possible and practical.' Semin Cancer Biol 23(6 Pt B): 492-501. Sierra, J. C., S. Hobbs, R. Chaturvedi, F. Yan, K. T. Wilson, R. M. Peek, Jr. and D. B. Polk (2013). 'Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells.' Am J Physiol Gastrointest Liver Physiol 305(2): G196-203. Sipponen, P. and A. B. Price (2011). 'The Sydney System for classification of gastritis 20 years ago.' J Gastroenterol Hepatol 26 Suppl 1: 31-34. Skinner, M. K., M. Manikkam and C. Guerrero-Bosagna (2010). 'Epigenetic transgenerational actions of environmental factors in disease etiology.' Trends Endocrinol Metab 21(4): 214-222. Smith, M. F., Jr., A. Mitchell, G. Li, S. Ding, A. M. Fitzmaurice, K. Ryan, S. Crowe and J. B. Goldberg (2003). 'Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells.' J Biol Chem 278(35): 32552-32560. Steel, H. C., A. J. Theron, R. Cockeran, R. Anderson and C. Feldman (2012). 'Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics.' Mediators Inflamm 2012: 584262. Stolte, M., A. Meining, H. Koop and E. Seifert (1999). 'Eradication of Helicobacter pylori heals atrophic corpus gastritis caused by long-term treatment with omeprazole.' Virchows Arch 434(1): 91-94. Sturgill, M. G. and R. P. Rapp (1992). 'Clarithromycin: review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles.' Ann Pharmacother 26(9): 1099-1108. Suerbaum, S. and P. Michetti (2002). 'Helicobacter pylori infection.' N Engl J Med 347(15): 1175-1186. Sung, J. J., W. K. Leung, M. Y. Go, K. F. To, A. S. Cheng, E. K. Ng and F. K. Chan (2000). 'Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions.' Am J Pathol 157(3): 729-735. Suzuki, M., H. Suzuki and T. Hibi (2008). 'Proton pump inhibitors and gastritis.' J Clin Biochem Nutr 42(2): 71-75. Takemura, T., D. N. Granger, D. J. Evans, Jr., D. G. Evans, D. Y. Graham, D. C. Anderson, R. E. Wolf, G. Cepinskas and P. R. Kvietys (1996). 'Extract of Helicobacter pylori induces neutrophils to injure endothelial cells and contains antielastase activity.' Gastroenterology 110(1): 21-29. Takeshima, E., K. Tomimori, R. Takamatsu, C. Ishikawa, F. Kinjo, T. Hirayama, J. Fujita and N. Mori (2009). 'Helicobacter pylori VacA activates NF-kappaB in T cells via the classical but not alternative pathway.' Helicobacter 14(4): 271-279. Talarico, S., S. E. Whitefield, J. Fero, R. Haas and N. R. Salama (2012). 'Regulation of Helicobacter pylori adherence by gene conversion.' Mol Microbiol 84(6): 1050-1061. Thiel, A., J. Mrena and A. Ristimaki (2011). 'Cyclooxygenase-2 and Gastric Cancer.' Cancer Metastasis Rev. Tong, L., Y. Yuan and S. Wu (2015). 'Therapeutic microRNAs targeting the NF-kappa B signaling circuits of cancers.' Adv Drug Deliv Rev 81C: 1-15. Vanaudenaerde, B. M., W. A. Wuyts, N. Geudens, L. J. Dupont, K. Schoofs, S. Smeets, D. E. Van Raemdonck and G. M. Verleden (2007). 'Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells.' Am J Transplant 7(1): 76-82. Waldum, H. L., O. Hauso and R. Fossmark (2013). 'The regulation of gastric acid secretion - clinical perspectives.' Acta Physiol (Oxf). Wang, J., L. Xu, R. Shi, X. Huang, S. W. Li, Z. Huang and G. Zhang (2011). 'Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta-analysis.' Digestion 83(4): 253-260. Watanabe, N., T. Shimada, Y. Ohtsuka, H. Hiraishi and A. Terano (1997). 'Proinflammatory cytokines and Helicobacter pylori stimulate CC-chemokine expression in gastric epithelial cells.' J Physiol Pharmacol 48(3): 405-413. Watanabe, T., M. Tada, H. Nagai, S. Sasaki and M. Nakao (1998). 'Helicobacter pylori infection induces gastric cancer in mongolian gerbils.' Gastroenterology 115(3): 642-648. Waugh, D. J. and C. Wilson (2008). 'The interleukin-8 pathway in cancer.' Clin Cancer Res 14(21): 6735-6741. Wen, S. and S. F. Moss (2009). 'Helicobacter pylori virulence factors in gastric carcinogenesis.' Cancer Letters 282(1): 1-8. Wen, S. and S. F. Moss (2009). 'Helicobacter pylori virulence factors in gastric carcinogenesis.' Cancer Lett 282(1): 1-8. Wong, B. C., L. Zhang, J. L. Ma, K. F. Pan, J. Y. Li, L. Shen, W. D. Liu, G. S. Feng, X. D. Zhang, J. Li, A. P. Lu, H. H. Xia, S. Lam and W. C. You (2011). 'Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions.' Gut. Yamazaki, S., A. Yamakawa, Y. Ito, M. Ohtani, H. Higashi, M. Hatakeyama and T. Azuma (2003). 'The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.' J Infect Dis 187(2): 334-337. Yanai, A., S. Maeda, W. Shibata, Y. Hikiba, K. Sakamoto, H. Nakagawa, T. Ohmae, Y. Hirata, K. Ogura, S. Muto, A. Itai and M. Omata (2008). 'Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.' Infect Immun 76(2): 781-787. Yang, J. C., T. H. Wang, H. J. Wang, C. H. Kuo, J. T. Wang and W. C. Wang (1997). 'Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients.' Am J Gastroenterol 92(8): 1316-1321. Yang, Y. X. and D. C. Metz (2010). 'Safety of Proton Pump Inhibitor Exposure.' Gastroenterology 139(4): 1115-1127. Yeo, M. (2006). 'Novel action of gastric proton pump inhibitor on suppression of Helicobacter pylori induced angiogenesis.' Gut 55(1): 26-33. Yoshino, N., S. Ishihara, M. A. Rumi, C. F. Ortega-Cava, T. Yuki, H. Kazumori, S. Takazawa, H. Okamoto, Y. Kadowaki and Y. Kinoshita (2005). 'Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa.' Am J Gastroenterol 100(10): 2157-2166. Zhao, Y., K. Yokota, K. Ayada, Y. Yamamoto, T. Okada, L. Shen and K. Oguma (2007). 'Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes.' J Med Microbiol 56(Pt 2): 154-164. Zuckerman, J. M. (2004). 'Macrolides and ketolides: azithromycin, clarithromycin, telithromycin.' Infect Dis Clin North Am 18(3): 621-649, xi-.zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/93060-
dc.description.abstract背景與目的:發炎相關的癌症是對於癌症防治的重要議題,幽門桿菌、胃炎與胃癌序列關係則是此類疾病最重要的疾病模式之一。近年來對於防治胃癌的共識為主要的策略就是根除幽門桿菌,本研究就臨床與分子觀點探討藥物與幽門桿菌對胃黏膜影響的微觀環境改變與分子效應。 研究方法:第一部分胃黏膜病理部份,收集病人有或無服用質子幫浦阻斷劑進行分析,以內視鏡切片術胃竇部黏膜組織,以福馬林保存送病理切片,再進一步進行病理染色。以雪梨胃炎分類系統為準則對胃黏膜的病理進行分析。第二部分藥物(omeprazole與clarithromycin)對於幽門桿菌在胃上皮細胞株的作用分析。以幽門桿菌萃取物處理細胞株,以兩株不同幽門桿菌株ATCC 43504 (cag A陽性) 與 ATCC 51932 (cag A陰性) 幽門桿菌菌體萃取物處理胃癌細胞株Kato-III,以西方墨點試驗觀察轉錄因子NF-κB活化有關之蛋白質的變化。以反轉錄聚合酶鏈式反應進行NF-κB相關細胞激素的表現。 結果: 第一部分共收集76位個案進行分析,其中44胃個案幽門桿菌感染,19位服用質子幫浦阻斷劑。服用質子幫浦阻斷劑組病人之胃黏膜中性球浸潤有較少白血球浸潤與淋巴球浸潤的現象,質子幫浦阻斷劑組有顯著的胃黏膜萎縮的現象,對於胃黏膜的腸道化生影響則無顯著的影響。以服用時間分析,病人服用質子幫浦阻斷劑時間愈長,胃黏膜中性球的浸潤愈少,此外,服用質子幫浦阻斷劑的時間對於胃黏膜幽門桿菌的數量有顯著的抑制作用。第二部分:幽門桿菌與omeprazole都會影響NF-κB與IkB的磷酸化的表現,幽門桿菌株ATCC 43504 (cag A陽性) 與 ATCC 51932 (cag A陰性)菌體萃取物處理胃癌細胞株Kato-III,NF-κB的表現會受到幽門桿菌的刺激而表現增加。也會誘發NF-κB相關細胞激素COX-2基因表現,但對於IL-6與IL-8不會誘發表現。Omeprazole只會抑制cagA陰性幽門桿菌所誘發的NF-κB表現。CagA陽性幽門桿菌所誘發的COX-2會被omeprazole所增強表現, CagA陰性幽門桿菌所誘發的COX-2會被omeprazole所抑制。若使用clarithromycin與幽門桿菌共同處理過的細胞,也發現的NF-κB 的表現降低。單獨使用clarithromycin處理, NF-κB 的基本表現量也會降低。細胞株經過48小時clarithromycin與幽門桿菌株 ATCC 43504 (cag A-positive)與ATCC 51932 (cag A-negative)的處理,降低 IL-8 mRNA 的表現。根據NF-κB傳統路徑有關的蛋白p65與替代路徑有關的蛋白p52,可被幽門桿菌活化,但被clarithromycin降解。 結論: 服用質子幫浦阻斷組病人之胃黏膜中性球浸潤有較少白血球浸潤與淋巴球浸潤,且有顯著的胃黏膜萎縮的現象。cag A陽性與cag A陰性幽門桿菌株皆可活化NF-κB的表現。Omeprazole對於幽門桿菌所處理為細胞株的NF-κB與相關細胞激素呈多型性影響。Clarithromycin則可透過傳統與替代路徑調控幽門桿菌所活化的NF-κB與IL-8zh_TW
dc.description.abstractBackground and aims:Inflammation associated cancer is one of the important issues in cacer prevention. Helicobacter pylori (H. pylori) related gastritis and cancer is one of the important disease models of inflammation assoicated cancer. The statement that eradication of H. pylori is the most effective method of primary prevention for gastric cancer. It the present study, we aimed to eludicate the interaction of drugs with H. pylori in the gastric microenviroment and molecular mechanism. Materials and Methods: The first part: Adult patients taking proton pump inhibitors (PPI)or not who received upper gastrointestinal endoscopy were enrolled. Endoscopic biopsies of gastric antral mucosa were performed and evaluated by H&E stain according to the update Sydney system. The second part: effect of omeprazole and clarithromycin on Kato-III cell line, which were stimulated with H. pylori water extracts (HPE) containing ATCC 43504(CagA+) and ATCC 51932(CagA-) strains. NF-κB activation, IκB expression and phosphorylation, and the cytokines expression were assessed in the absence and presence of omeprazole or clarithromycin. Results: The first part: Among the 76 patients, 44 patients had H. pylori infection and 19 patients had taken PPI prior to gastric biopsy with varying duration. Patients who taking PPI had significant less neutrophil and lymphomcyte infiltration in gastric mucosa, more gastric mucosa atrophy. Duration of PPI use is reversely correlated with neutrophil and H. pylori infiltration of gastric mucosa. The second part: Both H. pylori and ompeprazole affect NF-κB activation and IκB phosphorylation. CagA+and CagA- H. pylori induced NF-κB activation and COX-2 expression, whereas omeprazole suppressed NF-κB activation in the CagA- strain. CagA+ and CagA- HPE induced COX-2 expression, but no significant effect on IL-6 and IL-8. However, OMP downregulated the transcription of COX-2, IL-6, and IL-8 in CagA- HPE treated cells. Clarithromycin inhibited H. pylori-induced activation of NF-κB and associated upregulation of IL-8 expression. H. pylori activated NF-κB classical pathway associated protein p65 and alternative pathway protein p52, and clarithromycin degradated them. Cnclusion: PPI use is associated with less neutrophil and lymphocyte infltration of gastric mucosa, and related to the atrophy of mucosa. H. pylori induces NF-κB activation in a CagA-independent manner. CagA of H. pylori exerted different behavior of H. pylori induced NF-κB activation and associated cytokines expression. However, OMP suppressed NF-κB activation and associated cytokines also differently in CagA+ and CagA- HPE treated Kato-III cells. H. pylori-induced NF-κB signaling can occur through classical and alternative activation pathways, and CAM inhibits NF-κB these two pathways.en_US
dc.description.tableofcontents中文摘要 i 英文摘要 iii 目 次 v 表目次 vi 圖目次 vii 第一章 緒論 1 第一節 引言與背景簡介 1 第二節 研究假說 10 第三節 實驗研究設計 10 第二章 質子幫浦阻斷劑對胃黏膜微環境影響 16 第一節 前言 16 第二節 材料與方法 17 第三節 結果 18 第四節 討論 19 第三章Omeprazole與幽門桿菌在胃黏膜的相互作用 28 第一章前言 28 第二節 材料與方法 30 第三節 結果 31 第四節 討論 32 第四章Clarithromycin幽門桿菌在胃黏膜的相互作用 40 第一節 前言 40 第二節 材料與方法 42 第三節 結果 44 第四節 討論 45 第五章、結論 56 第一節 研究主要發現 56 第二節 研究特色與貢獻 57 第三節 未來展望 59 參考書目 61zh_TW
dc.language.isozh_TWzh_TW
dc.rights不同意授權瀏覽/列印電子全文服務zh_TW
dc.subjectclarithromycinzh_TW
dc.subjectomeprazolezh_TW
dc.subject質子幫浦阻斷劑zh_TW
dc.subject幽門桿菌zh_TW
dc.subjectNF-κBzh_TW
dc.subjectclarithromycinen_US
dc.subjectomeprazoleen_US
dc.subjectHelicobacter pylorien_US
dc.subjectNF-κBen_US
dc.subjectproton pump inhibitoren_US
dc.titleInteraction of Omeprazole and Clarithromycin with Helicobacter pylori in Gastric Mucosa Microenviromenten_US
dc.titleOmeprazole與Clarithromycin對幽門桿菌在胃黏膜微環境的相互作用zh_TW
dc.typeThesis and Dissertationen_US
dc.date.paperformatopenaccess2018-02-05zh_TW
dc.date.openaccess10000-01-01-
item.grantfulltextrestricted-
item.openairetypeThesis and Dissertation-
item.languageiso639-1zh_TW-
item.fulltextwith fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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