Please use this identifier to cite or link to this item:
|標題:||The effects of trivalent chromium on hormonal regulation in ovariohysterectomized rats
|關鍵字:||肥胖;卵巢子宮摘除;三價鉻離子;生長激素;第一型類胰島素生長因子;胰島素;obesity;ovariohysterectomized;trivalent chromium;growth hormone;insulin-like growth factor-I;insulin||引用:||Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 17: 548-555, 1998a. Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev 56: 266-270, 1998b. Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr 16: 404-410, 1997. Anderson RA. Recent advances in the clinical and biochemical manifestations of chromium deficiency in human and animal nutrition. J Trace Elem Med Biol 11: 241-250, 1998c. Anderson RA, Kozlowski AS. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am J Clin Nutr 41: 571-577, 1985. Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. Effects of chromium picolinate on food intake and satiety. Diabetes Tech Therapeut 10: 405-412, 2008. Attenburrow MJ, Odontiadis J, Murray BJ, Cowen PJ, Franklin M. Chromium treatment decreases the sensitivity of 5-HT2A receptors. Psychopharmacol (Berl) 159: 432-436, 2002. Bary GA. Etiology and pathogenesis of obesity. Clin Cornerstone 2: 1-15, 1999. Bideci A, Camurdan O. Physiology of growth hormone secretion. J Clin Res Ped Endo 1: 1-7, 2009. Bland IM, Guthrie-Jones RD, Taylor J H. Dog obesity: owner attitudes and opinions. Prev Vet Med, 92: 333-340, 2009. Brown RO, Forloines-Lynn S, Cross RE, Heizer WD. Chromium deﬁciency after long-term total parenteral nutrition. Dig Dis Sci 32: 661-664, 1986. Bunker W, Lawson MD, Delves HT. The uptake and excretion of chromium by the elderly. Am J Clin Nutr 39: 799-802, 1984. Cave NJ. The use of estradiol to normalize food intake in cats following gonadectomy, and the efﬁcacy and immunological effects of genistein as a surrogate estrogen. PhD thesis, University of California, Davis, CA. 2005. Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocr Rev 16: 117-142, 1995. Chen NSC, Tsai A, Duer IA. Effects of chelating agents on chromium absorption in rats. J Nutr 103: 1182-1186, 1973. Chowen JA, Frago LM, Argente J. The regulation of GH secretion by sex steroids. Eur J Endocrinol 151: 95-100, 2004. Clemmons DR. Clinical utility of measurements of insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab 2: 436-446, 2006. Cooke PS, Naaz A. Role of estrogens in adipocyte development and function. Exp Biol Med 229: 1127-1135, 2004. Colliard L, Ancel J, Benet JJ, Paragon BM, Blanchard G. Risk factors for obesity in dogs in France. J Nutr 136: 1951-1954, 2006. Davidson MB. Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev 8: 115-131, 1987. Dubreuil P, Pelletier G, Couture Y, Lapierre H, Petitclerc D, Morisset J, Gaudreau P, Brazeau P. Castration and testosterone effects on endogenous and somatocrinin-induced growth hormone release in intact and castrated male pigs. Dom Anim Endocrinol 6: 15-24, 1989. Fanciulli G, Delitala A, Delitala G. Growth hormone, menopause and ageing: no deﬁnite evidence for rejuvenation with growth hormone. Hum Reprod Update 1: 1-18, 2009. Frandson RD, Wilke WL, Fails AD. Anatomy and physiology of farm animals. 7th ed. Wiley-Blackwell, Iowa. 528, 2009. Frick F. GH, IGF-I and insulin in the regulation of lipid and lipoprotein metabolism. 2001. Geary N, Asarian L, Korach KS, Pfaff DW, Ogawa S. Deﬁcits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice. Endocrinology 142: 4751-4757, 2001. Geary N, Trace D, Mcewen B, Smith GP. Cyclic estradiol replacement increases the satiety effect of CCK-8 in ovariectomized rats. Physiol Behav 56: 281-289, 1994. German AJ. The growing problem of obesity in dogs and cats. J Nutr 136: 1940S-1946S, 2006. German AJ, Martin L. Feline obesity: epidemiology, pathophysiology and management. In: Pibot P, Biourge V, Elliott D, eds. Encyclopedia of feline clinical nutrition. Aimargues, France: Aniwa SAS 4-43, 2008. Gibney J, Wolthers T, Johannsson G, Umpleby AM, Ho KK. Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men. Am J Physiol Endocrinol Metab 289: 266-271, 2005. Gossellin J, Wren JA, Sunderland SJ. Canine obesity: an overview. J Vet Pharmacol Ther 30: 1-10, 2007. Guilliams TG, Edwards L. Chronic stress and the HPA axis: clinical assessment and therapeutic considerations. The Standard 9: 1-12, 2010. Hobbs CJ, Plymate SR, Rosen CJ, Adler RA. Testosterone administration increases insulin-like growth factor-1 levels in normal men. J Clin Endocrinol Metab 77: 776-779, 1993. Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR, Bruce-Robertson A. Chromium deficiency, glucose intolerance and neuropathy reversed by chromium supplementation in a patient receiving long term total parenteral nutrition. Am J Clin Nutr 30: 531-538, 1977. Jeusette IC, Lhoest ET, Istasse LP, Diez MO. Influence of obesity on plasma lipid and lipoprotein concentrations in dogs. Am J Vet Res 66: 81-86, 2005. Kandror KV. Insulin regulation of protein traffic in rat adipocyte cells. J Biol Chem 274: 25210-25217, 1999. Kotryna Š. Alterations in peripheral glucocorticoid metabolism: effects of weight changes. 2011. LeRoith D, Werner H, Beitner-Johnson D and Roberts CT, Jr. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16: 143-163, 1995. Lucassen EA, Cizza G. The hypothalamic-pituitary-adrenal axis obesity and chronic stress exposure sleep and the hpa axis in obesity. Curr Obes Rep 1: 208-215, 2012. Lund EM, Armstrong PJ, Kirk CA, Klausner JS. Prevalence and risk factors for obesity in adult cat from private US veterinary practice. Intern J Appl Res Vet Med 3: 88-96, 2005. Luque RM, Kineman RD. Impact of obesity on the growth hormone axis: Evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147: 2754-2763, 2006. Louveau I, Bonneau M, Salter DN. Age-related changes in plasma porcine growth hormone (GH) profiles and insulin-like growth factor-I (IGF-I) concentrations in Large White and Meishan pigs. Reprod Nutr Dev 31: 205-216, 1991. Martin LJ, Siliart B, Dumon HJ, Nguyen P. Spontaneous hormonal variations in male cats following gonadectomy. J Feline Med Surg 8: 309-314, 2006a. Martin LJM, Siliart B, Dumon HJW, Nguyen PG. Hormonal disturbances associated with obesity in dogs. J Anim Physiol Anim Nutr 90: 355-360, 2006b. Meij BP, Kooistra HS, Rijnberk A. Hypothalamus-pituitary system. In: Rijnberk A, Kooistra HS, eds. Clinical endocrinology of dogs and cats. 2nd ed. GmbH, Schlutersche 13-54, 2009. Mertz W. Chromium in human nutrition: a review. J Nutr 123: 626-633, 1993. Sloth C. Practical management of obesity in dogs and cats. J Small Anim Pract 33: 178-182, 1992. Mertz W, Roginski EE, Schwarz K. Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats. J Biol Chem 236: 318-322, 1961. Morris RM, Griffith H, Kemp GJ, Wallch S. Clinical and biochemical aspects of chromium deficiency. J Am Coll Nutr 4: 107-120, 1984. Muir P, Johnson KA, Manley PA. Fractures of the pelvis. In: Birchard SJ, Sherding RG, eds. Saunders manual of small animal practice. 2nd ed. Philadelphia: WB Saunders Co 1126-1132, 2000. Offenbacher EG, Pi-Sunyer FX. Chromium in human nutrition. Ann Rev Nutr 8: 543-563, 1988. Onakpoya IJ, Wider B, Pittler MH, Ernst E. Food supplements for body weight reduction: a systematic review of systematic reviews. Obesity 19: 239-244, 2011. Pechova A, Pavlata L. Chromium as an essential nutrition: a review. Vet Med 52: 1-18, 2007. Pechova A, Podhorsky A, Lokajova E, Pavlata L, Illek J. Metabolic effects of chromium supplementation in dairy cows in the peripartal period. Acta Veterinaria Brno 71: 9-18, 2002. Pitler MH, Stevinson C, Ernst E. Chromium picolinate for reducing body weight: meta-analysis of randomized trials. Int J Obes 27: 522-529, 2003. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoid: new mechanisms for old drugs. N Engl J Med 353: 1711-1723, 2005. Rogers NH, Perfield II JW, Strissel KJ, Obin MS, Greenberg AS. Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology 150: 2161-2168, 2009. Rose AJ and Herzig S. Metabolic control through glucocorticoid hormones: An update. Mol Cell Endocrinol, 2013. Schwarz K and Mertz Z. Chromium (III) and glucose tolerance factor. Arch Biochem Biophys 85: 292-295, 1959. Seale JV, Wood SA, Atkinson HC, Bate E, Lightman SL, Ingram CD, Jessop DS, Harbuz MS. Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats. J Neuroendocrinol 16: 516-524, 2004. Sjoberg A, Oscarsson J, Olofsson SO, Eden S. Insulin-like growth factor-I and growth hormone have different effects on serum lipoproteins and secretion of lipoproteins from cultured rat hepatocytes. Endocrinology 135: 1415-1421, 1994. Smith SR. The endocrinology of obesity. Endocrin Metab Clin 25: 921-942, 1996. Sloth C. Practical management of obesity in dogs and cats. J Small Anim Pract 33: 178-182, 1992. Tannenbaum GS, Ling N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 115:1952-1957, 1984. Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocr Rev 15: 80-101, 1994. Vegiopoulos A, Herzig S. Glucocorticoids, metabolism and metabolic diseases. Mol Cell Endocrinol 275: 43-61, 2007. Vincent JB. Recent developments in the biochemistry of chromium (III). Biol Trace Elem Res 99: 1-16, 2004. Vincent JB. The biochemistry of chromium. J Nutr 130: 715-718, 2000. Ducros V. Chromium metabolism. Biol Trace Elem Res 32: 65-77, 1992. Yang WZ, Mowat DN, Subiyatno A, Liptrap RM. Effects of chromium supplementation on early lactation performance of Holstein cows. Can J Anim Sci 76: 221-230, 1996. Yu H, Rohan TJ. Role of the insulin-like growth factor family in cancer development and progression. Natl Cancer Inst 92: 1472-1489, 2000. Zha LY, Wang MQ, Xu ZR, Gu LY. Efficacy of chromium(III) supplementation on growth, body composition, serum parameters, and tissue chromium in rats. Biol Trace Elem Res 119: 42-50, 2007. Zoran DL. Obesity in dogs and cats: a metabolic and endocrine disorder. Vet Clin North Am Small Anim Pract 40: 221-239, 2010.||摘要:||
節育已經被證實是導致伴侶動物肥胖的主要風險因素之一。造成節育後肥胖的影響因素有許多，其中有些研究探討節育後賀爾蒙的變化，發現節育會造成影響葡萄糖及脂肪代謝賀爾蒙的平衡發生改變。三價鉻離子是一種動物體內不可或缺的微量元素，其對於葡萄糖、脂質及蛋白質代謝很重要。此外，有研究顯示三價鉻離子可藉由像是減少攝食量及增加代謝速率的機制進而減少體重。故本研究欲探討給予三價鉻離子對於節育動物體重和身體組成的變化及節育後賀爾蒙的影響。本實驗將8週齡的雌性大鼠分為4組 (n=6/組)，給予生理食鹽水之大鼠為控制組 (C)，給予三價鉻離子之大鼠為鉻離子組 (Cr)，給予生理食鹽水及進行子宮卵巢摘除手術之大鼠為子宮卵巢摘除手術組 (OHE)，給予三價鉻離子及進行子宮卵巢摘除手術之大鼠為鉻離子及子宮卵巢摘除手術組 (Cr+OHE)，每天給予並在給予後一週進行子宮卵巢摘除手術，之後持續給予13週。每週秤量各組大鼠的體重及攝食量，並在實驗大鼠14、18及22週齡時採集血液檢測生長激素、第一型類胰島素生長因子 (IGF-I)、胰島素及醣皮質固醇的濃度。在實驗的最後，進行腹腔注射葡萄糖耐受性試驗 (IPGTT)。結果顯示子宮卵巢摘除手術組 (OHE) 和鉻離子及子宮卵巢摘除手術組 (Cr+OHE) 的生長激素濃度在三個時間點都較控制組低，其中鉻離子及子宮卵巢摘除手術組 (Cr+OHE) 的生長激素濃度有隨著實驗的時間較久而呈下降的趨勢，甚至在22週齡時達顯著差異 (P < 0.05)。而子宮卵巢摘除手術組 (OHE) 和鉻離子及子宮卵巢摘除手術組 (Cr+OHE)的血中第一型類胰島素生長因子在14週齡及18週齡均顯著高於控制組。子宮卵巢摘除手術組 (OHE) 和鉻離子及子宮卵巢摘除手術組 (Cr+OHE) 的血中醣皮質固醇的濃度在14週齡時均較控制組低，但只有子宮卵巢摘除手術組 (OHE) 具顯著差異。而在14週齡時，子宮卵巢摘除手術組 (OHE)、鉻離子組 (Cr) 和鉻離子及子宮卵巢摘除手術組 (Cr+OHE)，血中胰島素濃度都較控制組高，其中鉻離子及子宮卵巢摘除手術組 (Cr+OHE) 具顯著差異 (P < 0.05)。在葡萄糖耐受性試驗中，雖然子宮卵巢摘除手術組 (OHE) 和鉻離子及子宮卵巢摘除手術組 (Cr+OHE) 的葡萄糖曲線下面積都低於對照組，但只有鉻離子及子宮卵巢摘除手術組 (Cr+OHE) 具顯著差異 (P < 0.05)。然而，子宮卵巢摘除手術組 (OHE) 的胰島素曲線下面積顯著高於控制組。綜合以上結果，本實驗顯示給予三價鉻離子具有調節子宮卵巢摘除手術大鼠體內荷爾蒙的作用，並可改善節育後的胰島素敏感性。
Neutering has been identified as an important risk factor of obesity. Many factors seem to be involved, but a number of studies have shown that neutering modifies hormone balance, and these modiﬁcations of hormonal factors involved in glucose and fat metabolism. Trivalent chromium (Cr3+) is an essential nutrient required for glucose, lipid and protein metabolism, and is necessary for insulin function. Cr3+ has also been suggested to reduce body weight by a number of mechanisms, such as reduce food intake and increasing metabolic rate. In this study, all 8-week-old SD female rats were divided into four groups (n=6): (1) control group, (2) ovariohysterectomy (OHE) group, (3) Cr3+ supplement group, (4) OHE with Cr3+ supplement group. OHE was performed after one week of supplemental Cr3+, the regimen of supplemental Cr3+ were continued for 13 weeks. Body weight and food intake were recorded weekly. Evaluation of circulating growth hormone (GH), insulin-like growth factor-I (IGF-I), insulin and corticosterone (CORT) concentrations at different time points. At the end of experiment, intraperitoneal glucose tolerance tests (IPGTTs) were conducted after overnight fasting. In results, both OHE groups had lower GH levels than control group. And the GH levels of OHE with Cr3+ supplement group were gradually decreased and even were significantly lower compared with control group at 22-week-old. The IGF-I levels in both OHE groups were significantly higher than that in control group at 14- and 18-week-old. The levels of insulin at 14-week-old were higher in OHE group, Cr3+ group and OHE with Cr3+ supplement group, however the insulin level of OHE with Cr3+ supplement group was significantly higher than that in control group. Lower CORT levels were found in both of OHE groups than that in control group, but only significantly lower in OHE group at 14-week-old. During the GTTs, the area under the curve (AUC) glucose in OHE and OHE with Cr3+ supplement group were lower than that in control group, but only OHE with Cr3+ supplement group had significant difference. However, AUC insulin was significantly higher in OHE group than in control group. According to the results of this study, the daily supplementation of Cr3+ to OHE rats affects hormone status and can improve insulin sensitivity.
|Appears in Collections:||獸醫學系所|
Show full item record
Files in This Item:
|File||Description||Size||Format||Existing users please Login|
|nchu-103-7101038007-1.pdf||1.23 MB||Adobe PDF||This file is only available in the university internal network|
TAIR Related Article
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.