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標題: Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy
作者: Wang, Sin-Ting
Huang, Shi-Wei
Kao, Jun-Kai
Liang, Shu-Mei
Chen, Yi-Ju
Chen, Yu-Yu
Wu, Chun-Ying
Shieh, Jeng-Jer
關鍵字: AMPK;Apoptosis;Autophagy;Imiquimod;AMP-Activated Protein Kinases;Adenosine Triphosphate;Aminoquinolines;Antineoplastic Agents;Apoptosis;Autophagy;Carcinoma, Basal Cell;Carcinoma, Squamous Cell;Cell Line, Tumor;Down-Regulation;Enzyme Activation;Gene Silencing;Humans;Melanoma;Myeloid Cell Leukemia Sequence 1 Protein;Myeloid Differentiation Factor 88;Phosphorylation;Protein Biosynthesis;Protein-Serine-Threonine Kinases;Signal Transduction;Skin Neoplasms;Toll-Like Receptor 7;Toll-Like Receptor 8
Project: Journal of dermatological science, Volume 78, Issue 2, Page(s) 108-16.
AMP-activated protein kinase (AMPK), a principal intracellular energy sensor, plays a crucial role in cell growth, proliferation, apoptosis and autophagy. Imiquimod (IMQ) directly exhibits anti-tumor activity through the induction of apoptosis and autophagic cell death.
DOI: 10.1016/j.jdermsci.2015.02.008
Appears in Collections:生物醫學研究所

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