Please use this identifier to cite or link to this item:
|標題:||Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response||作者:||Lin, Ming-Kuem
|關鍵字:||Contact hypersensitivity response;Dendritic cell;Immunosuppression;Taiwanofungus camphoratus;Zhankuic acid C;Animals;Anti-Inflammatory Agents;Basidiomycota;Cell Line, Tumor;Chemokines;Cytokines;Dendritic Cells;Dermatitis, Contact;Dose-Response Relationship, Drug;Ergosterol;Humans;Lipopolysaccharides;Mice;Molecular Conformation;Structure-Activity Relationship;Immunosuppression||Project:||Bioorganic & medicinal chemistry letters, Volume 25, Issue 20, Page(s) 4637-41.||摘要:||
Some ergostane triterpenoids from Taiwanofungus camphoratus have been shown to exhibit anti-inflammatory activity in vitro. However, the effect of ergostane triterpenoids on the immune response remains unknown. In this study, we elucidated that ergostane triterpenoids significantly decreased the cytokines and chemokine release by dendritic cells (DC) and that, in the case of zhankuic acid C (ZAC), the decrease was dose-dependent and inhibited DC maturation. ZAC inhibited the contact hypersensitivity response and infiltrative T cells in the ears of DNFB-stimulated mice. Thus, we demonstrate for the first time that ZAC exhibits an immunosuppressive effect on DC activation and the contact hypersensitivity response. It is suggested that ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.
|Appears in Collections:||生物醫學研究所|
Show full item record
TAIR Related Article
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.