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標題: Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response
作者: Lin, Ming-Kuem
Lee, Meng-Shiou
Chang, Wen-Te
Chen, Hsing-Yu
Chen, Jin-Fu
Li, Yi-Rong
Lin, Chi-Chen
Wu, Tian-Shung
關鍵字: Contact hypersensitivity response;Dendritic cell;Immunosuppression;Taiwanofungus camphoratus;Zhankuic acid C;Animals;Anti-Inflammatory Agents;Basidiomycota;Cell Line, Tumor;Chemokines;Cytokines;Dendritic Cells;Dermatitis, Contact;Dose-Response Relationship, Drug;Ergosterol;Humans;Lipopolysaccharides;Mice;Molecular Conformation;Structure-Activity Relationship;Immunosuppression
Project: Bioorganic & medicinal chemistry letters, Volume 25, Issue 20, Page(s) 4637-41.
Some ergostane triterpenoids from Taiwanofungus camphoratus have been shown to exhibit anti-inflammatory activity in vitro. However, the effect of ergostane triterpenoids on the immune response remains unknown. In this study, we elucidated that ergostane triterpenoids significantly decreased the cytokines and chemokine release by dendritic cells (DC) and that, in the case of zhankuic acid C (ZAC), the decrease was dose-dependent and inhibited DC maturation. ZAC inhibited the contact hypersensitivity response and infiltrative T cells in the ears of DNFB-stimulated mice. Thus, we demonstrate for the first time that ZAC exhibits an immunosuppressive effect on DC activation and the contact hypersensitivity response. It is suggested that ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.
DOI: 10.1016/j.bmcl.2015.08.038
Appears in Collections:生物醫學研究所

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